ID A0A3P9C2T2_9CICH Unreviewed; 1132 AA.
AC A0A3P9C2T2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rap associating with DIL domain {ECO:0000313|Ensembl:ENSMZEP00005016409.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005016409.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005016409.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005016409.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9C2T2; -.
DR Ensembl; ENSMZET00005016929.1; ENSMZEP00005016409.1; ENSMZEG00005012266.1.
DR GeneTree; ENSGT00940000159293; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd15472; Myo5p-like_CBD_Rasip1; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd17116; RA_Radil_like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR037983; CBD_Rasip1/Radil.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR16027; DILUTE DOMAIN-CONTAINING PROTEIN YPR089W; 1.
DR PANTHER; PTHR16027:SF3; RAS-ASSOCIATING AND DILUTE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 64..174
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 546..828
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 1035..1120
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1132 AA; 124887 MW; C6B031AB503FAE2F CRC64;
MFYGSSSGAS MSLPSKSRLK RQSRTFTQVL YRTLSYRDRD RRSTTEPPER PADDPAELST
QSSAPGVLKI FGDEICAGAN YKSVLATPRS SAQELVKEAL ERYSLNKDAA HSYVLCDVIG
RFEGGGVIGG GEGGGWRTEC LRALGDNEKP LLLQELWKPR EGHARRFELR RRAEVEELNA
KEKDTITADI NAQARKLQRN RAKGTLTLPR SSNSSFCRSL SETSLNQLGL GEEPKRYYST
LPGPLRGRER EGTSSSRRKE ESSQGGGGGG VKHSLYQSPH LLLLQGFNRQ DCLVYLLNRE
QHTVGQETPS ARPNICLFSP DILPLHCRLR RVPAPRRHAS NNNKGEEQGE SQRFCVAVEA
VLNATVLVNF SRCERSTTLR HGDLLSFGAH YIFLYKDPTG SKPLPAQTLA RLRTLGQLYD
AGAEEGEGGA QTCKMCGSVL KERAAQVSST PAVRRGGQKR RLQLEFDQAH EDQLLNRIVS
LIEPGGDDHK LTPAYLLCMC IQHSASTFPP GSFGKLLLKI VRRIQSIAWE KTKELAQKQA
QHQDPASLSL LSISDLVPDL QTIFFWMSNS IEILYFIQQR APAYTHSIET LQGSKESLLS
ATISANEEAM TILEEVIMYT FQQCVYYITK ALYVVLPGLL DCNPFPVDSS EPCWKGGVGF
PEPVRRVLQV FQSAQELLQG YQVHPEIQAQ MFAYLFFFSN VSLFNQLMDK GPSRGWFQRS
KMLQIQACLR MVMEWASRSG LGHLAEKFFT KLNSTVSILA THPQQLTQLG WRALSSEHPT
LKPVQLHRIL TQYQLTAEIG PVPTWQPSSE DEPYIYRTVD LLESFENHPP IVLPSSGFRV
DLDSECVEDS IYRQLLYIRH YLWGLRTKTQ THTNTPSVQT HSNGTNTADW PEVQRELLPP
SHSSPRSGGP GDDGPGEPGE ERGRDRPSGQ SHTHSLRRNG TIHHPRTANP DPSCLLTPPN
TPLYPEGGGG GGPVPLIGTN VQTNGCTGRT VAECKKTNGL ITNGLEGCIS GCEFPFPVSS
PGVPSLPDDL CVVFVVELDK GPYGLGMGLI DGLHTPLNAP GIYIRTLIPD GPAASDGRLR
IGDRILAVNG TSLIGADYQS AVDLIRLGGG RLRFLVAKSD PEVSEKISAS SC
//
