ID A0A3P9C3Z7_9CICH Unreviewed; 1185 AA.
AC A0A3P9C3Z7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSMZEP00005016993.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005016993.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005016993.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005016993.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P9C3Z7; -.
DR STRING; 106582.ENSMZEP00005016993; -.
DR Ensembl; ENSMZET00005017533.1; ENSMZEP00005016993.1; ENSMZEG00005012739.1.
DR GeneTree; ENSGT00940000158693; -.
DR Proteomes; UP000265160; LG8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 750..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..1002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..335
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 765..1016
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 520..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 135286 MW; 8AC882564B42BFDB CRC64;
MNHHISQHKR HASEVFGGGG RYSWIPKIIK KRVCSTFVED SFSSSEFCQC GAARDDHASV
AVGDYFSTAI LKHWESAEHS SEQPTDAFGE VQFAGASKRH SHFLRLSWST EPSVVYNILT
AQSIWGLPRP NLVVSVVGGE SRTQVKTWVR EVLRQGLVKA SQSTGAWILT TGLREGVGRC
VGQAVRDHAA AASSVSLNKV VALGIAPWGL VKKREQLVNP QGSFPAKYYV HNISRDSCYL
DNNYQAFLLV DDGSVGRRGG ETDFRARLEE YISQQRTGIW GSGSIDIPVL CMLISGEADT
LKRMDLSLKN FIPWLVVAGS GGLADFLSDV LENLSSAPAV PSSGEGNNEA LKAPNVDLKD
RVAERFKKHF PSETETDKLV EQALSIYQNR HLITVYHGEH ESPNDFDTVL LKTLVGAEDN
PYTDELKLAV TWNRVDIAKT ELFNGDIQWK YEDLEDSMTD ALINNKPQFV RLFIENGLNI
LEYLTYGRLE TLYRSVPDGS LLYQLLQRCL AERLAMVERH SPSEQQNSSS KVATDNNQSR
PVKEVSEVLE LLMGDVCQPF YYKHSFLHSS KRASKVLRGH CMYQDLPCPH PWASLFLWAV
LQNRSEMALY FWEMAGEAVL SALGGCKILR ELSKLDEETE TKLSMKELAQ KFENLAHDIF
SSCYRSNEHR SFTLLIRKSP VWGHSTCLQM GVSADARLFF SNDGVQVCSV FNLFHSCDFS
PPALYERKEK ESVPYRPPQR PFIVSRWCQF WFAPVTSFLG NVLMYFLFLL FFAYVLLADF
KPPPPSGPGA AECVLYFWVF TIVCEEIRQT IFLGTMTWRQ RFRLYIKDVW NKCDLTAISL
FIIGLICRMF HLSHEFGRDM LCLDYMVFTL RLIHIFAIHK QLGPKIIIVG KMIKDIFFFL
FFLGVWLMAY GVANQALIYA YDPNPNRIFR RVFYRPYLHI FGQIPVEEMD VGKDWDITCT
HNVTLIESGE EPCRSHESNW LVVILLVVYL LVTNILLINL LIAMFSYTFS KVQEHSDIYW
KFQRYNLIVE YHSRPALAPP FIILSHINLF IKRVIRKVPS VKIHHFVLDL EPKAANRLST
WETIQKEDFL TAQNKIQKSS DSERLKRMSA KVDGVLKHLS ESRDFEHRLR SLENQMDYCS
SALSWVVDTL AQGSTFKPPR PPPASRGMIT KQPAIFQYCF QYKLS
//
