ID A0A3P9C494_9CICH Unreviewed; 1256 AA.
AC A0A3P9C494;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSMZEP00005016864.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005016864.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005016864.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005016864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P9C494; -.
DR Ensembl; ENSMZET00005017403.1; ENSMZEP00005016864.1; ENSMZEG00005012655.1.
DR GeneTree; ENSGT00940000158693; -.
DR Proteomes; UP000265160; LG8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 743..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 982..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1086
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..331
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 849..1100
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 143063 MW; 2F9C252DD81B54B9 CRC64;
MKDTGAEERG GGDGRDNIGQ TEKSQSWIPK IIKKRVCSTF VEDSISNGAL CQCGAARDDH
ASVALGDYFS TAIVNQWKSV QHSSERPTDA FGEVQFAGAS KRHSHFLRLS WSTEPSMVYT
ILTAHWRLPL PNLVVSVVGG EGRTQVKTWV REVLRQGLVK ASQSTGAWIL TTGLREGVGR
CVGQAVRDHA TAASSFSLNK VVALGIAPWG LVEKREQLVN PQGSFPAKYY VQNISRDSCS
LDNNYQAFLL VDDGRVGRRG GETDFRARLE EFISQQRAGI WGSGSIDIPV VCMLISGETD
MLKRMDLSLK SCIPWLVLAG SGGLADFLSD ILENRSSAPA VPSSGEGNSE APKTPSVDLK
DRVAERFKKH FPSEAQTDKL VEQALSIYQN KDLITIYQGE HESPNDFDTV LLKTLVGASK
QQSSVDASPY SDELKLAVTW NRVDIAKSEL FNGDIQWKYE DLEDSMTDAL INNKPQFVRL
FTENGLNILE YLTYGRLETL YRSVPDGTLL YQLLQQCLAE RLAIVERHSP SEKQNSSSKM
VKDNNQDGPV KEVTLFEVSG VLELLMGDVC QPLYYKALGL QFTSSKRTSL RRANKVLRGD
SFYRQLRCPY PWASLFLWAV LQNRSEMALY FWEMAGEAVL SALSGCNILR DLSKLEEETE
TKLSMKELAQ KFENLAHDIF SSCYRSDENR SFTLLIRKSP IWGDTTCLQM GVSADARLFF
SNDGVQSLLS QIWWGDMKRN TEVWKLLLAF FCPILCYTNL ISFRTQDNQL EEEEMPNEDA
VAQDSDNLYG TTVFSFSDIK QHEVDSDVHK SDAIKGVPYR PPQRPFIVSR WRQFWFAPVT
SFLGNVLMYF LFLLLFAYVL LVDFEPPPPS GPGAAECVLY FWVFTIVCEE IRQTIFLGTM
TWRQRFRLYI QDVWNKCDLT AISLFIVGLI CRMFHWSYEF GRDVLCLDYM VFTLRLIHIF
AIHKQLGPKI IIVGKMMKDV FFFLFFLGVW LMAYGVANQA LIYSYDPNLN RIFRRVFYRP
YLHIFGQIPV EEMDVGKDWD VNCTHNVTLI ESGEEPCRTH ESNWLVVILL VVYLLVTNIL
LINLLIAMFS YTFSKVQEHS DTYWKFQRYN LIAEYHSRPS LAPPFIILSH INIFIRRVIR
KVPSVKIHHF VLDLEEKAAN RLSMWETIQK EDFLTARIKI QKSSDSERLK RMSAKVDGVL
KHLSESRDFE HRLRSLENQI EYCSSAISWV VDTLAQGSTF KPPRPPPALR GTSQNL
//
