ID A0A3P9C4P1_9CICH Unreviewed; 787 AA.
AC A0A3P9C4P1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005017009.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005017009.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005017009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; A0A3P9C4P1; -.
DR STRING; 106582.ENSMZEP00005017009; -.
DR Ensembl; ENSMZET00005017551.1; ENSMZEP00005017009.1; ENSMZEG00005012746.1.
DR GeneTree; ENSGT00940000154910; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..787
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018322557"
FT DOMAIN 23..191
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 188..381
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
SQ SEQUENCE 787 AA; 88982 MW; 664F8FDFA8D246EF CRC64;
MGMYLHLLLL QYYFVSSFVC NAIAFVEEPF GGRSDGYCGR ILRAQTHGTR RDGHHEFRLR
VEGDPDTYRP GSTYRVVLLA TSPAYFRGFT LIALKEGREG TTDDDYTGQF QIIDEDETQF
MTNCPPAVTE STPRRRTRIQ VLWTAPPSGT GCVILKASIV QKRVIYFQDE GSLTVQLCEK
EGEATQAPAI ECCACGTAKY RLTFYGNWSE KVHPKDYPRR ANHWSALIGA SHSRSYVLWE
YGGYASEGVR QVAEFGSPIK MEEEIRQKGD EVLTVIKTKA QWPAWQPLNL RAAPSAEFSV
DRTRHLMSFL TMLGPSPDWN VGLSGEDLCT KECGWVQRLE TDLIPWDAGT DSGVTYESPN
KPTVPQEKIR PLTSLDHLQS PFYDPEGGAI TPVARVVVER IARKGEQCNV VPDTIDDIVA
DIGQEEKETD DTPETCIYSG WSPWSACSSS TCEKGRRMRQ RMLKAQLDLS VPCPHTQDFQ
PCMGPGCSRE EPSTCMMSEW ISWSACSVSC GMGMRSRERY VKQYPEDGSL CQLNTEETEK
CVVNDECSPS SCVVTEWGEW DPCSVTCGIG MRRRERMVKM PPIDGSMCKT EVAEVEKCMM
PECHTIPCML SPWSEWSECS VTCGRGIRTR QRMLKSDPAE CTEELEQTEK CMLPECPVDC
MVSEWTEWSE CNKTCGKGHT IRTRMIKVEP QFGGSYCPET IQRKKCKLRK CRRKPIKEEE
VPGWSNNEQI VCFIPSGCRM QPWSSWTECT KPCGGGIQER FRVAKKRTKS KGCKDRKEIR
ACNAREC
//
