ID A0A3P9C556_9CICH Unreviewed; 754 AA.
AC A0A3P9C556;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kirre like nephrin family adhesion molecule 2 {ECO:0000313|Ensembl:ENSMZEP00005017410.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005017410.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005017410.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005017410.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_004541609.1; XM_004541552.1.
DR AlphaFoldDB; A0A3P9C556; -.
DR STRING; 106582.ENSMZEP00005017410; -.
DR Ensembl; ENSMZET00005017962.1; ENSMZEP00005017410.1; ENSMZEG00005013098.1.
DR GeneID; 101479283; -.
DR CTD; 557315; -.
DR GeneTree; ENSGT00940000160603; -.
DR OrthoDB; 5362512at2759; -.
DR Proteomes; UP000265160; LG11.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0032836; P:glomerular basement membrane development; IEA:Ensembl.
DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR GO; GO:0039022; P:pronephric duct development; IEA:Ensembl.
DR GO; GO:0039021; P:pronephric glomerulus development; IEA:Ensembl.
DR CDD; cd05759; IgI_2_KIRREL3-like; 1.
DR CDD; cd05758; IgI_5_KIRREL3-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..754
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018179213"
FT TRANSMEM 493..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..386
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..486
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 542..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 81493 MW; BD65B4C1B473BEF1 CRC64;
MSSLYLIFCV MVTAATQAAY FSQQPQDQVV VSGQSVTLPC VIVGYRGMVQ WTKDGLALGG
ERDLPGWTRY SLMGDPLSGE HSLQIDSAEL ADDAVYECQA TQAALRSHRA KLTVLVPPSD
PVVEGGPVVR LKAHTPHNLT CRASGAKPAA EITWYRDGEV METAIYSKSL MEDRKRETAV
SMLPIIPEDS DSGRTYTCRV VNPAAPAGRQ TSVTINVQHP PSVTLSVQPQ TVTEGAKVLF
ICSASANPEI TGYRWSKGGV PISEANGDSL EVTVDYSYFT DPVSCEVSNS VGSTNVSTLV
DVQFGPRLLS EPKPMTVDTG MDAAFTCAWT GNPPLTLAWT KQGSSVVLSN GNTLQLKAVT
QEDAGTYTCK AIVPRIGVAE RDVTLTVNGP PIITAEATQH AVKHSKGKLE CRVGSSPPPD
KIVWTFGDMS LSSGSSGRYS VQTVTSDHGV VSSLVLSETL SQDFQLRYNC TAWNRFGTGT
ALVTLKEQEA LPMLIIVGGA VGGGCVLLIC VITLVSLCCR HTGKGKRCTR LSKSDIRVQI
VHSDHNATRG NDDEEDVKEP MAPNSSESPG TSRTEHSDLL EEEEDERSDI KDPTNGYYNV
RGHDDRHIRG SGFSEYVPNS RPVYTPSQLP SPSPVYGQHG TQPRAYDFSH RYATTTVSRT
SYEQQQAAQQ QPAQQGGVYP TDPLYSGTAY LPATYGHAFT SYVKPASYEK VDAYDQSDQA
SKVSSSSRFS YASSQVSSQQ SDYGRPSQRM QTHV
//
