ID A0A3P9C5M0_9CICH Unreviewed; 924 AA.
AC A0A3P9C5M0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=VPS10 domain-containing receptor SorCS3 {ECO:0000313|Ensembl:ENSMZEP00005017392.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005017392.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005017392.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005017392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A3P9C5M0; -.
DR STRING; 106582.ENSMZEP00005017392; -.
DR Ensembl; ENSMZET00005017944.1; ENSMZEP00005017392.1; ENSMZEG00005013059.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 2.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 861..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..652
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 680..731
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 924 AA; 104805 MW; 8C09168FB48BC13D CRC64;
IMVLTDPEFE SSVLISTDEG ASYQKYRLNF YLLSLLFHPT EEDWALAYSH DQKLYSSVDF
GRKWQLIHEH VTPNRFYWSV TSLDKEPDLI HMEAHTPDGN VQYVTCRAQM CTEANRNYPF
PGYIDISSLV VQDDYIFIQV PTSGRATYYV SYKREPFIQI KLPKYSLPKD LHIVSTDEKQ
VFAAVQEWNQ NDTYNLYLSD TRGIYFTLAM ENVKTTRGIG GNQMLDLYEV AGIKGMLIAN
KRHDNQVKTY ITYNKGRDWR LLQAPASDLE GNDIHCILPF CSLHLQLQMS ENPYLSGTIS
TKNSAPGMIV ATGNIGAELS YNNVGMFISS DAGNTWRPIF EEEHNIWFLD KGGALVAVKQ
PSVPTRHLWV SFDEGRQWTQ HSFSSVPLFV DGVLVEAGAE NQIMTFFGHF SHRSEWQLIK
IDYKSIFSRK CTEEDYQTWH LHNQGEPCVM GQKQIYMKRR PGNYCMLGKD YSRILSAESC
ICRAHDFECD YGYERSSDGN CKPAFWFNPS TVSRSCSQGQ NYFNSTGYRK VVLNNCTKGV
KELYTPRKQQ CPNRPPKGLL LTTKDGKLTA SLGSNVTFMV HLDEGDSLRT NIQLDFGDGT
AVSYSNLSWT EEGIKHVYKS AGIFRVTAFA ENTLGYDTTT LYLHVTCPVE HVQLLAPFVV
IRNKEVNITA VVLPSHSRTV TYFWWLGNNT EPVITLDGSI SHTFQSEGMH TITVQVAASN
TILQDTKTIA VKEFFKSLLL SFSPNLDEFN PDIPEWRQDV GRVIKKVAEF PEEQLLVAVF
PGVPTAAELF LLPYKNQSEG KKKSEEALER VWVSLSEIHE DALNQNLVEF ELKPGVRVIV
YNTQLTLAPL VDSSPRHSSS AMLMLLSVVF LGLAVFLIYK FKSRVLGCNL LMNVNLGLRL
HSLRNTTTPL CACTNTAPAR EMVI
//
