ID A0A3P9C6N1_9CICH Unreviewed; 563 AA.
AC A0A3P9C6N1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Alpha-2-macroglobulin {ECO:0000313|Ensembl:ENSMZEP00005017719.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005017719.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005017719.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005017719.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9C6N1; -.
DR Ensembl; ENSMZET00005018286.1; ENSMZEP00005017719.1; ENSMZEG00005012623.1.
DR GeneTree; ENSGT00940000162996; -.
DR Proteomes; UP000265160; LG3.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF150; ZGC:171445 PROTEIN-RELATED; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018282078"
FT DOMAIN 466..557
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 563 AA; 63201 MW; CAE8D50E410AF5CC CRC64;
MGSMLITVFK QTLFFAFVNN NCCMCDAVCS QYLVAIPAVI EAGAEAKFCA TLRQPSGTLV
MTVTLMSREK NTTLFTHTSN EAFQTCVQFE APLVQKEVQH FQVEVRGDTF YSKQVRKVMI
RASDTFTFIQ TDKPIYLPGQ KVNFRVVAMD NKMRPANQLD PHSNRIGQWL NETSNSRILQ
LSYSLDAEAP EGPYQIIVSM GERKISHNFK VEKYVLPKFD VTVNISEEVS IGQEDVEAKV
YTYGQPVPGR VTVNVCRPIN LQVSLLCLDD KTGCATFSFN MSIFTKMDQK VLQDVLDIRA
KVEEEGTGKL CYSFKMTHQC IVTISYVLGK VSFINVPKVW ERGSNVEGKV SLTSMGNPAL
ALYSTLVFSA EGWSTVTVQA PSSQLTFDVN QGNKLLYQEE ALQDVSGKYR LEVKGTACAS
VQISATYNIP TPADVTTLSV RVHLEVNTSE SARPKFTVYS GKEETTNMVI LDIKMLSGFS
PDPESLKSLK RGLLVSRVEQ KEDHVLVYIE ELSKDTPINH SLEIIQELPV DNLKPAVVKI
YDYYQPVTQR NDTFMFFYHV SVR
//
