ID A0A3P9C7A7_9CICH Unreviewed; 812 AA.
AC A0A3P9C7A7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mucosa-associated lymphoid tissue lymphoma translocation protein 1 {ECO:0000313|Ensembl:ENSMZEP00005018153.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005018153.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005018153.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005018153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_004575685.1; XM_004575628.2.
DR AlphaFoldDB; A0A3P9C7A7; -.
DR Ensembl; ENSMZET00005018742.1; ENSMZEP00005018153.1; ENSMZEG00005013636.1.
DR GeneID; 101473126; -.
DR CTD; 10892; -.
DR GeneTree; ENSGT00390000018044; -.
DR OrthoDB; 3080800at2759; -.
DR Proteomes; UP000265160; LG12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd08783; Death_MALT1; 1.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.3360; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR037940; MALT1_Death.
DR InterPro; IPR041077; MALT1_Ig.
DR InterPro; IPR033540; MALT1_IG-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR PANTHER; PTHR22576:SF40; MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF18703; MALT1_Ig; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 105..181
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 206..286
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..439
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 812 AA; 91622 MW; 8731AB5BCB331595 CRC64;
MSDSLERSTK INSLKEPVVK RLCEVLDKSS TKGWRKLGEI VGNDRRFKVS SDDMEMCSLK
VLELEGSPSL MLLRLMGERG CTTGHLMDYL QTLGNSEALQ CLKPPALQIL IQPQSVSIIC
GHNLRLSCHA VGKSPVQYQW FKSKEEVPNS FSPDLVISPV QMKDAGFYIC RVNCGDAFEF
SHWAQVDVLN VTLCYGQSYH FLDGRQKVVI QPQSQRLHVG EDLQLECGAV GRPIPRYQWH
RNGVPIPNST KRKLMIPHVM QEQQGRYRCE ISSSSERMWT NEVDVVIDDI YAIGEGSNEF
FLNSIPEQLY ATDKVALLIG NLSYQNHPQL KAPMVDVYDL TNLLRQLNFK VVSLLDLTES
EMRNAVDEFL LLLHKGVYGL LYYAGHGYEN YGNSFMVPVD APNPYRSANC LCVQSILKLM
QEKETDLNVF LLDMCRKRNI HDDSTSNVVL RVTANIVFGY ATCQDAEAFE LSSTGFTNGV
FVKFLKKRLL DDEKITVVLD RVAEDMGQFD ATKGKQALEI RSSLSERRAL TDPILPGDSA
DLAHAHSRQW AKAHELPESM CLNFDCGAQI KLGFAAEFSN VLVIYTHIVK KPTDMSFCQA
HVTDFSQDLD VDPKLMNRET PEETGIYLLS SSLPQHCLYT RLSSLQKLRE ELVFTVCLQG
TFTAMDDDHP IHWTKSVNIG KPLIARLDLH RAMRRNSCLQ TCLMPHSPSH SPCHSPGPEH
RHHLYHGSHQ AQDYNRLSPQ HRYLDIGEHL QGAVGGCGDI YYENLSQCRY DPPYTSGGLS
SSPGRLSIPI ETTDDINELQ TVFINSLQLQ PQ
//
