ID A0A3P9C7U7_9CICH Unreviewed; 405 AA.
AC A0A3P9C7U7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Serpin H1 {ECO:0000256|ARBA:ARBA00013551};
DE AltName: Full=Collagen-binding protein {ECO:0000256|ARBA:ARBA00030441};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005018139.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005018139.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005018139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds specifically to collagen. Could be involved as a
CC chaperone in the biosynthetic pathway of collagen.
CC {ECO:0000256|ARBA:ARBA00025405}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR RefSeq; XP_004543967.1; XM_004543910.3.
DR RefSeq; XP_012772668.1; XM_012917214.2.
DR AlphaFoldDB; A0A3P9C7U7; -.
DR STRING; 106582.ENSMZEP00005018139; -.
DR Ensembl; ENSMZET00005018728.1; ENSMZEP00005018139.1; ENSMZEG00005013629.1.
DR GeneID; 101483538; -.
DR KEGG; mze:101483538; -.
DR CTD; 30449; -.
DR GeneTree; ENSGT00940000156163; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000265160; LG14.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF27; SERPIN H1; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..405
FT /note="Serpin H1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017931859"
FT DOMAIN 39..396
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 405 AA; 45389 MW; 85354D272799BA72 CRC64;
MWMTNIVGLC LLALVASAED VKLSTHATAL ADKSTNLAFS LYHTMAKEKD TENIIISPVV
VASSLGLVAL GGKASTASQV KTVLSADKLK DEHLHAGLSE LLTEVSNAKT RNTTWKINNR
LYGPSSVSFA DEFVKNSKKH YNYDHSKINF RDKRSAVNSI NEWAAKSTGG KLPEVTKDVQ
NPDGAMIVNA MFFKPHWEEK FHDKMVDTRG FLVTRSFTVG VPMMHRTGLY DFYEDTENKV
FVLNMPLGQK QASMILIMPY HLEPLERLEK LLTRKQVDTW LSKMENRAVA ISLPKISVEV
SHNLQKHLAE LGLTEAVDKA KADLSNISGK KDLYLSSVFH ASALELDIEG NPYDTSIFGT
EKLRNPKLFY VDHPFIFLVK DNKTNSILYI GRVVKPKGDK MRDEL
//
