ID A0A3P9C848_9CICH Unreviewed; 847 AA.
AC A0A3P9C848;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Leucine-rich repeat flightless-interacting protein 2 {ECO:0000313|Ensembl:ENSMZEP00005018445.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005018445.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005018445.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005018445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LRRFIP family.
CC {ECO:0000256|ARBA:ARBA00008275}.
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DR AlphaFoldDB; A0A3P9C848; -.
DR STRING; 106582.ENSMZEP00005018445; -.
DR Ensembl; ENSMZET00005019040.1; ENSMZEP00005018445.1; ENSMZEG00005013851.1.
DR GeneTree; ENSGT00530000063564; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.5.4090; -; 1.
DR InterPro; IPR019139; LRRFIP1/2.
DR PANTHER; PTHR19212; LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN; 1.
DR PANTHER; PTHR19212:SF5; LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1; 1.
DR Pfam; PF09738; LRRFIP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..251
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..438
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95288 MW; 5772D034E9E71DFC CRC64;
MGTQGPGRKR IPNREKLTGE DDALNQIARE AEARLAAKRA ARAEAREIRM KELERQKEIS
DDEERMSVGS RGSLRPSDYS GFLGSGSRAS SRASSARASP VVEERTDREF PDKGSRTAST
LSAATLASLG GASSRRGSCD TSFSVETEAS IREMKDSLAE TEEKYRKAMV SNAQLHNEKS
TLMYQVETLR EELNEMEELL WETRRRCDDA HKEWERERHA HSLLQFHFKD MKETLRKTEE
LLTEVADLRL KSSSYCQEVS DLQEALQWKD KKIGALERHR EISDIVCIER DRLRDEVVRL
RDLLKKNGVT ISPDITTNGD AELGGNEDDI SAESASRLAQ ESPQGGRENM LGKTKEWETK
EGNRPPENNK KNYLWKVLKQ SKSLNDISTI SKSKLIKQPI ERQNTADKHL GGNEAARTKQ
PRPKRIKKIQ SRQHGRLLHR KKGAKLRMNK ERPGAACKIY EPKMATKPKN EFGLVSTAPA
NQDPTEETHS FSEQISKTQE NSEKCPEVVS PVLKSKLFHH PTEHVIQDSK VVLLSVSSHN
CDVSGSVEKV QMDKDTFHET AQSPEELKDQ RIHEPARHSS SKCAERNIQT STSFAPLDIC
AGLEKMTQNI HQGFAGNQVF VVEISQIFSE ILGSLQKWTS DVENILKNKP SQHNKEQTGH
MMDPTLKKHV EKCLTRPLGL LRDHSASRML EVASTSKLHA DNLDRPMNAD QKAQRIMSKT
HEMEVVELFG GNPADIDETT VTSCSEPFVF IDSYFTKPEE ATAKVSGSNL GSSTSSKRFK
SQSCHVVAAK NSKELVGDTD SCEEINEDGQ QMEMEALAEV GSMKCRRRQR ESCSDCRKNK
KSECSIS
//
