ID A0A3P9C9M7_9CICH Unreviewed; 1376 AA.
AC A0A3P9C9M7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSMZEP00005018797.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005018797.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005018797.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005018797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR Ensembl; ENSMZET00005019401.1; ENSMZEP00005018797.1; ENSMZEG00005014078.1.
DR GeneTree; ENSGT00940000162790; -.
DR Proteomes; UP000265160; LG4.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF143; BROMODOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 56..128
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 369..441
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 625..707
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..935
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1376 AA; 153298 MW; 2B988BC9637A41E0 CRC64;
MGDGLDTAQM SGSTSSQGQV QQQCNPPPPE YINPNRPKRQ TNQLQYLLKV VVKTLWKHQF
AWPFHAPVDA LKLNLPDYYT IIKTPMDMGT IKKRLENSYY WNAQECIQDF NTMFTNCYIY
NKPGDDIVLM AEALEKVFLQ KVSEMPQEET EIVVMTGKGR GRGRREGGLN LKPGAIMDPL
STTPQTRGLS ALPTGLQTRG PVQGPPSLPP QPLMQALAGH VPPALSSHAP QLGAPFSLGQ
SDCPPQVPVM TSVPPPSQTS LPPATIQSTA PMLQTSMTMT KSQKRKADTT TPTANDQLSE
SSPAESKSGK TLPRRESARP TKIKKDAPDS QHHIGLGMGL SGPSGGHSPK PQDQLGYCAS
LVREMLSKKH AAYAWPFYKP VDVDALGLHD YHDIIKHPMD LSTIKAKLEN RQYRDPQEFA
ADVRLMFSNC YKYNPPDHEV VAMARKLQDV FEMRFAKMPD EPESKPLVSA PAPALHHPAP
VKPQPPLAHV ASSSDSSSDS SSESESSTDD SEEERAQRLA ELQEQLKAVH EQLAALSQPQ
ASKPKRKEKE KKEKKKDKHK RKGSMPVDEI QDATPLSQPS KKIKTSNNNN KEIVPKKKPS
KKETMKPASL QPVPSLEDDL GATLSSVTGE KCKPMTYEEK RQLSLDINKL PGDKLGRVVH
IIQSREPSLK NSNPDEIEID FETLKPSTLR ELERYVSSCL RKKKRPMATS KKTGSSSDSS
GSSSDSEVEV PGTIKQPKRK NHAVKEGKGK THSHIQTLPA QATHQSQAAG LQSSSQMKQQ
QHHHHHQPSP AGFMAPSVAP LESSQLLETS FDSLPPFGQP IMHMSHHTGN ASSSPAPSHL
NTHSAGPVSP ETHPFLNQHS VLPSPALHSS MPQQPSRPSH KAAPLHPKPP QQPAPPQQPQ
QQQQPPLQQQ PPLQQLQPQP LPQPQPTPLH QRPISPPTLT PQGLLSSQPP QMLLEDDEEP
VSTTPINQLF LPQFQQPRQT QQARQQQQQP VQTSLLQSVQ TQSQLSSQTT LAPAQHPVQS
QQQQQQPQQQ QVNYQHCPIL PPQSQGTQHK ASMPTNKTQQ IIQQQQQELP SPRPTKPDPY
NTGHMRDNPS PLMMNSPQLP QYPPVSHQSP PHNMQPKKQR APGTQGVLKE EKLPPSPVMR
GEPFNPAMRP DHHKHPESKP CQPSHSQQTD VKSMEGSRPV IRSAEPSGPP TSLQDKEKFK
QESKAPSAPK KVQDVKLKNM GSWASLAQKS TSTPLSAVKS SSDSFEQFRR AAREKEEREK
ALKAQAEQAE KDRLRREQDK LRGRDEEEVM EQSRRMHDEP RRRLEQPHIQ APSQQQHQQQ
QQQQQQSVQQ ESQPPAIQQP PQPPTPPQLT TQNQLDQERE RARLREQERR RREAVR
//
