ID A0A3P9CAL6_9CICH Unreviewed; 554 AA.
AC A0A3P9CAL6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=E3 ubiquitin-protein ligase RNF220 {ECO:0000313|Ensembl:ENSMZEP00005019044.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005019044.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005019044.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005019044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CAL6; -.
DR Ensembl; ENSMZET00005019657.1; ENSMZEP00005019044.1; ENSMZEG00005014266.1.
DR GeneTree; ENSGT00390000016573; -.
DR Proteomes; UP000265160; LG18.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16563; RING-HC_RNF220; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031824; RNF220_mid.
DR InterPro; IPR040178; RNF220_RING.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13459:SF1; E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1; 1.
DR PANTHER; PTHR13459; UNCHARACTERIZED; 1.
DR Pfam; PF15926; RNF220; 2.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 502..541
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 326..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 60610 MW; F8D0FF988CE2A1F4 CRC64;
MDLHRAAFKM ESSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV PVSVEKDVHL
PFNNGSYTFA SMYHRQGAVP PGFPNRDFPP SLLHLHHQFA PPNLDCSPIS MLNHSGVGAF
RPFASPPEDR DGAPGGYQSA FTPAKRLKGC LDAESSPHLR YSDAEGKEYD FGGAQIPPGG
SPSSALKAVE DSGKKIFAVS GLLSDRETSS SPEDRIERCK KKMSLYDSQA PVCPICQVLL
RPGELQEHME TEIERLATIC LSSKNPSSKD GAATPGTPKS MLLSVHIKRE GESPVVSPLS
SEDAHHSDRY QVTHTWAHTH IHTHTNKGSL RESSEFPDCD DDSADMDGEN GRGFEEYEWA
GQKRIRATAL LEGGFRATGF ATCSIKESAA DSDADLDVDG DDTLEYGKAQ YTEADIIPCS
GAGEDQGEAR EREALRGAVL NGGMPSNRIT PEFSKWASDD PSTPSEIEKV TEEESTATTM
EALKARIREL EKQILRGDRY KCLICMDSYT MPLTSIQCWH VHCEECWLRT LGNKKLCPQC
NTITSPGDLR RVYL
//
