ID A0A3P9CAM3_9CICH Unreviewed; 1180 AA.
AC A0A3P9CAM3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Leptin receptor {ECO:0000313|Ensembl:ENSMZEP00005019338.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005019338.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005019338.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005019338.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_004568955.1; XM_004568898.2.
DR AlphaFoldDB; A0A3P9CAM3; -.
DR STRING; 106582.ENSMZEP00005019338; -.
DR Ensembl; ENSMZET00005019964.1; ENSMZEP00005019338.1; ENSMZEG00005014517.1.
DR GeneID; 101484846; -.
DR KEGG; mze:101484846; -.
DR CTD; 3953; -.
DR GeneTree; ENSGT00730000111209; -.
DR OrthoDB; 5344962at2759; -.
DR Proteomes; UP000265160; LG17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041182; LEP-R_IGD.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF7; INTERLEUKIN-21 RECEPTOR; 1.
DR Pfam; PF18589; ObR_Ig; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 10..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..336
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 527..623
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 964..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 131653 MW; 905587A0602720F0 CRC64;
MLAVSAGNKL FYLSLLDIWW CGAAVRFTTA KAYVVHALVM TATMVQSVML TGLVSVFLVS
YGAQSLKPKD GASLRSGAGD LPWQDELCCE SPSAHLGVEG GSANSPEANL SQSNLPHSPG
CTFKSSRIDS HHPRSSGGTC LDILCRIDGN WQNLICDLRS RGQPSDSLMA VSLRRQLFQQ
DGDYPASENP VVCEAQDSFM CSLTLDPTTS FVAMVTVSIS DAVAPPVLLR VPARPEKPSP
PGNLSHTQTI EAELIVLWDD PADFDAGPLR YEVRYSSGTT HPACQVVSAP GEPRVSLDLK
PKLNYTVQVR CSGPEEPPLW SEWSEPHHIR LDTVSYIPKK VVARPRENVT VYCVFNDHRM
NASMAVWKLN FQPLPPPTLY HPVNQWVSKI TLHPSENQMY DLLRCTEEWS IPYSQIYVEG
ADIDIKCVTN GDIDAMDCSW THKQPDKLKF QSKWADLPCD EMEERERAGE NLGEMSPACM
EGRQKTCTIH PLRMNCYKLW LELPSQLGPI RSKPVYLSPV DHVKPHAPAN VKAVSHSSGV
LEVTWQAPPL PVDGLQCQFQ YYSPSTVSPQ PKWKLQDPVR VLWAEVAVPD MCRVYVVQVR
CKHTNGTGYW SDWSESVYST PQNSRAPERG PDFWRIRQDD PHGNQSNITL LFENFPPSGN
SYCVDGFIVQ RRSSSGSVLR EKIELTSSYS FEWNQELQTV TVEAYNSLGT STDNINMTLE
RQPKGRCVRS FHVLLINSTC VSLSWSLLEN SLVPLFMVVE WLPHKQQDSG PRAETWARLH
YTDHPVYLRG DFFASEEYGF FLYPVFAEGE GEPIYTLATR GDPEAYMMLM IISFLFIILF
VTLVLSQNQM RKFVWKDVPN PRKCSWAKGI DFKKVDTFDY LFRPQEGLPV WPLLMPSENI
SQVIIVDKVL TTALIQNPLP DPADALAGSH SPGFDLNVDQ FMENETLPVE GPSSAVLDML
TTSSPRADDL QPADPSVDQH PGSTDNSGQS SVTYTAVLVS NPGQDQQPPI HLPYKDGSDN
SSSDEGNFSA NNSDISGSFP GGLWELESCR GLEMDDPRRS CSNNSVEELS QTSDQEDEHG
VRREKDLYYL GMDYPAEDEE SEKDDEQSED EEAKVELLKS TPLNRGHCSV ELHPLLSQDN
PSEPGILPSP STCGFAMPYL PQFRTATCTV QHTQLEPSCD
//
