ID A0A3P9CBI3_9CICH Unreviewed; 1610 AA.
AC A0A3P9CBI3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Kinesin-like protein KIF26A {ECO:0000313|Ensembl:ENSMZEP00005019364.1};
GN Name=KIF26A {ECO:0000313|Ensembl:ENSMZEP00005019364.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005019364.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005019364.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005019364.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 106582.ENSMZEP00005019364; -.
DR Ensembl; ENSMZET00005019992.1; ENSMZEP00005019364.1; ENSMZEG00005014535.1.
DR GeneTree; ENSGT00940000159075; -.
DR Proteomes; UP000265160; LG15.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21608:SF5; KINESIN-LIKE PROTEIN KIF26A ISOFORM X1; 1.
DR PANTHER; PTHR21608; UNCHARACTERIZED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 72..414
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 13..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1073..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1510..1537
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 565..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 160..167
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1610 AA; 172633 MW; CC8CA5A02617FA9F CRC64;
QIMDWKELAA HKLSLSRRKK SPPGSASLPG ESPEPLLYTG GFSGALQLSP PAIPPCLLRA
GSKVKDTPGM GKVRVMVRIC SVQDESSESM SFLKVDGRKK QLTLCETSAQ RRSSASAPKT
FTFDAIFSQD ASQAEVCSGT VAEVIQSVVN GADGCIFCFG HAHLGKTYTM IGRDCSTQSL
GVAPTAISWL FNVIEDRKEK SGACFSVRVS AVEISGREET LTDLLAELAA AGHQEAPGPA
VLLREDPICG SQLQNQIEVR ASSAERAASF LDAALAARKS NQMPNNQEVR RNSHFLFTLH
LYQERLDKSN KAAMSSRSRL HLLDLGSCET DISRTREGGG GQCLSFSALG NVILALANGA
KHVPYRDSKL TMLLRESLGN INCRTTMIAH ISDSPAGYME TLTTVQLAYR IHRMRKKKSK
HASSSSGGES SCEEGPSCRP PRLRPFHPLT VALDPDVPLL LSSDPDYSSS SEHSCDTVIY
VGPGGKAISD RELSDNEGPP SFVPIIPSLN KKRVKDAPKS DGDHFKCNTF AELQERLDCI
DGSEGPAMFG TEKKSVALKA QSGPLKPTEA TSPPKSEKNS SHMFSESTLT TFIDKSDQDQ
PKLPSAGGFI ETSKRTSADG EKLSGTPVQP CVVKSGGAPT HDSEPVVREK VYLRGAVPKP
LASPSLPRTT RTAPRPKEAL GRTPPVSISE QAMRQDQPPK SISPNLNTDG AAHTSRYPTE
VNNLRASLLG RCLDGDFLRT TITLQQPVEL NGEDELVFTV IEELPHSLVP DNGRPSNLLS
FNTDCFPQTL AAGSRPVSII SSINDEYDAY TSLQGAVGPG TDVGTEHQQG LLSHNKKQPS
VGSWLCESAE GDGIHSQSRL YLRDKTMDNA TLLSSPCIFH KHGVCFSELE SDPASPNKPS
FTKCPPSPKS AKASLKGSLK VKANTLNTSV STQIPRHATH SSLPRKTKPT SSAAVGCSRQ
EGRQDDVLLQ RSSYCDTREA EFLSASKPTR SGVTNVSSKR SGGNSNSVPR PPKMQMSSSA
QRVVDGCEKS SSRRGDTLIK LPRLTRGATT LGTVSTPQEA ASVISTLRFS SLGKKANGQK
SSTKFGQSSQ EQKLRIVLSP SALKTSSNTG KSSEDEVHVK LRAGSFSHRT SSFKTEHSFA
RTSSSLKTQG AKDSSRYFGS LMSLERCDSP TLAGSKPELF RENSGATSGG NGRSNRSVPR
LSDPASTSTS AFPSQVPAGV FAATSKLWQV RSGSGSRGAA SGGLKLRTLS ASTSKSPSSS
PKLPENVAGC NTNLPSNGKS PSRSGTGGKT VKGTIMGTKQ TIGRAANSRI SELVSGSQRK
MFGGGAGSDI PGSRTGSITG SPLNAPLPSP YSKITAPRRP QRYSSGHGSD NSSILSGELP
PAMGRTALFY HSGGSSGYES MIRDSETTGS TSSAHDSMSE SRASSSNRSR VSKSPKKRGN
GFLRRRLIPA PLPDTSSLGR KLGGQWVDLP PLGGTLKEQF EIKVYEIDNV ECVQKRKEGL
LYFNARLRML EKRQQQIQEL KSKHDRLKAE LEEAKSWLML HPSRWSGEFD VDQDLDCESQ
EYLEALAQAT GELEYCVNLC KSRLMMETCF DITVMTAGDA AQGGRQEVEV
//
