ID A0A3P9CDX9_9CICH Unreviewed; 549 AA.
AC A0A3P9CDX9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005020101.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005020101.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005020101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CDX9; -.
DR Ensembl; ENSMZET00005020748.1; ENSMZEP00005020101.1; ENSMZEG00005015031.1.
DR GeneTree; ENSGT00940000156613; -.
DR Proteomes; UP000265160; LG6.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF52; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 29..59
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 459..491
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 549 AA; 61221 MW; 5D3424A24EDFE8C7 CRC64;
RWCRPRRLPV EVPARRCDER CSGAPPTRYR GFDCRNNLFY SQAGEVVYHV AAVAVVYNRL
QHSQRFYLGH DDDILSLAVH PLKDYVASAQ VCPADRSMLH PAIHVWDIQT LKCLSLLKGH
HSRGVCALEF TGKLTARRGG LTFKRGIFGN LGKQETMMSA CYGRSEDLVF SGATNGDVYI
WRDTMLIKTI KAHDGPVFAM FNFTNLSRAL LLRPHLTEIE SLQCTDTVTC TPHTCVCQGH
MEGEVWGLAA HPLLPVCATV SDDKTLRIWE LSANHRMVAV RKLKKGETTL AVGLNDGSFL
VVNADTLEDM VTFHHRRELI SDIRFSQDAG KYLAVASHDS FVDIYNVLTS KRVGICKGAR
SYVTHIDWDS RGKLLQVNTG AKEQLFFEAP RGRRQNISVA EVRSLEWASW TSVFGPTCEG
IWPTLSFINA ASLTKDRKLL ATGDDFGFLK LFSFPSRKYV GHSSNVTNVR WSNDDTVLLT
VGGADTALMI WTRELPAPIT PSGPSSFSSW PLYHPSFLGS FPFIAPLPAK SVPLFVDAVD
LRFPFSPVP
//
