ID A0A3P9CG22_9CICH Unreviewed; 691 AA.
AC A0A3P9CG22;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Staufen double-stranded RNA binding protein 1 {ECO:0000313|Ensembl:ENSMZEP00005020811.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005020811.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005020811.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005020811.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_004548784.1; XM_004548727.2.
DR AlphaFoldDB; A0A3P9CG22; -.
DR STRING; 106582.ENSMZEP00005020811; -.
DR Ensembl; ENSMZET00005021494.1; ENSMZEP00005020811.1; ENSMZEG00005015605.1.
DR GeneID; 101477164; -.
DR KEGG; mze:101477164; -.
DR CTD; 6780; -.
DR GeneTree; ENSGT00940000157304; -.
DR OrthoDB; 2882160at2759; -.
DR Proteomes; UP000265160; LG5.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19879; DSRM_STAU1_rpt1; 1.
DR CDD; cd19881; DSRM_STAU1_rpt2; 1.
DR CDD; cd19887; DSRM_STAU1_rpt5; 1.
DR Gene3D; 3.30.160.20; -; 5.
DR Gene3D; 6.10.250.1360; -; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF2; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 4.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 72..139
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 155..254
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 276..343
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 378..446
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 75481 MW; C3AEF5DF84A28D13 CRC64;
MSQLQFQCPA SPMPAASAPL QPQPSYSIPC ASGTLPSESA SQPIRSSALP AGSATPYNST
TVSNMANPKE KTPMCLVNEL ARFNKIQPEY KLLCEQGPAH SKIFSVRLTL GDQHWEAEGT
SIKKAQHSAA ASALAETTLP KPTVRTPRST GKHQDGMTHI TELSALCIKL GKKPLYKPID
AYTGMRPPNF NYNVRAPGPY QRSMQQYYYP FPPVGPMIYH VELSIGGQQF FGKGRTRQLA
KHDAAAKALK VLQKEPILQQ LPVVNGEPEE ENLNKSEISQ VFEIALKRNL PVSFEVLKEE
GPPHMKTFVV RVTVGEFTGE GEGKSKKIAK KLAAAAVLGE LKRLPHIPSV EKTQPRIKKK
TKSIIKLQTS PEYGQGMNPI SRLAQIQQAK KEKEPEYSMV TERGLPRRRE FVMQVTVCGQ
SAEGMGPSKK VAKRNAAEKM LELLGYKVPQ PQPPKPALKT DEKTPVKKPG DGRKVTFYEP
GSVEEGTLGS KEEDFRLPYL SHQQLPAGIL PMMPEVAQAV GACQGSQAKD YSRSIPNPGK
TTITAMIANE LLYAGTSLTA ETILKTKNNM NQLPHGPLTR PSEQLGYLAS VQGLQVEYKD
FPKNNKNEFV SLINCSSQPP LISHGIGKDV ESCHDMAALN ILKLLSELDQ QSNERTGNGP
VSGCGKQEIE GDLHIKQANS STLAQTLDGT V
//
