ID A0A3P9CGC5_9CICH Unreviewed; 387 AA.
AC A0A3P9CGC5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=C1q and TNF related 4 {ECO:0000313|Ensembl:ENSMZEP00005020911.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005020911.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005020911.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005020911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CGC5; -.
DR STRING; 106582.ENSMZEP00005020911; -.
DR Ensembl; ENSMZET00005021598.1; ENSMZEP00005020911.1; ENSMZEG00005015697.1.
DR GeneTree; ENSGT00940000161832; -.
DR Proteomes; UP000265160; LG1.
DR Gene3D; 2.60.120.40; -; 2.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR22923; CEREBELLIN-RELATED; 1.
DR PANTHER; PTHR22923:SF87; COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4; 1.
DR Pfam; PF00386; C1q; 2.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 2.
DR SUPFAM; SSF49842; TNF-like; 2.
DR PROSITE; PS50871; C1Q; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..387
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018043253"
FT DOMAIN 29..168
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT DOMAIN 226..370
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 172..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43484 MW; 55E05231FEE3CBCD CRC64;
MLLPAGLLIV LLCLSHMGSA WGFAHLLDDV ELRSAFSVAR TSSMEGGPKM TVTFDAVYVN
IGGDFDAKSG LFRCRIPGAY YFSFTVGKFP HKDLSVMLMK NRNEVQAIVY EENAGEERKV
QSQSVMLQLE FGDTVWLRLH GDPRYALYSN TGHYTTFNGY LVYPDVYGYQ THHHHHQQHA
DSEQPLQDNI PLPSDNQATD HVRPGMTDGE KEPQMKEEEE EEEDEEDDQR SAFSVGRTQS
IVGVNQLGMP QHQPVSFDTA FVNIGEDFNV TEGVFTCRIP GAYYFSFNVG KMPQKTLSVK
LMKNRLEVQA MIYDDSQGEK ALQSQSLMLS LKPGDTVWLY SHQRDGFGAY SNHAKYITFT
GFLVYPDFPA AATTNTATSQ SYADKKP
//
