ID A0A3P9CL97_9CICH Unreviewed; 1035 AA.
AC A0A3P9CL97;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|Ensembl:ENSMZEP00005022586.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSMZEP00005022586.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005022586.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005022586.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005022586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3P9CL97; -.
DR Ensembl; ENSMZET00005023335.1; ENSMZEP00005022586.1; ENSMZEG00005016880.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000265160; LG9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 71..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..251
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 363..648
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 662..780
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 782..1035
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1035 AA; 114830 MW; 8F30E971733B517C CRC64;
PFINNTDDKG NSYDGTNMAL FEEEMDSNPM VSSFLSKLAN YTNLSQGAQE HEEADDDEGP
KKKASPQMGT FMGVYLPCLQ NILGVILFLR LTWIVGTAGI LESLAIVGLC CSCTMLTAIS
MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGSMYILGT IEILLTYMVP
KAAIFVADKK EDELDALLNN MRVYGTCCLA IMSVVVFVGV KYVNKLALVF LACVILSILA
IYAGVIKTIF DPPYFPVCML GNRTLKNHQF DKCNKIEVID NITVTTQLWN LFCDGSQLNA
TCNEYFVNNN VTELQGIPGL ISGVISENMW STYGPLGMLV EKSNLPSVEG GDPTQDIYMP
YVVNDITTFF TLLVGIYFPS VTGIMAGSNR SGDLRDAQKS IPIGTILAIT TTSIIYITSV
VLFGACIEGV LLRDKFGDSV KGNLVIGTLS WPSPWVIVIG SFFSCCGAGL QSLTGAPRLL
QAIARDGIVP FLQVFGHGKA NGEPTWALLL TAGICEIGIL IASLDSVIPQ VYSCLQFFLM
CYLFVNLACA VQTLLRTPNW RPRFKYYHWA LSFLGMSLCL AIMFISSWYY AIVAMVIAGC
IYKYIEYRGA EKEWGDGIRG LSLNAARYAL NRLEDAPPHT KNWRPQLLVL LNVDSDQAVK
HPRLVSFTTQ LKAGKGLTIV GNVLQGTYLT KESESKKAEQ NIKAAMSAER TKGFCHVVVS
SNLRDGVSHL IQSAGLGGMK HNTVLMAWPG AWKQSNDPQS WRNFIETIRE TTAAHQALLV
AKNVDSFPTN QDRLGEGTID VWWVVHDGGL LMLLPFLLRQ HKVWRKCKMR IFTVAQMDDN
SIQMKKDLQM FLYHLRLDAE VEVVEMHDND ISAFTYEKTL VMEQRSQMLK QMHLSRTERE
REAQLIHDRN TASHATINDK VDAEPEQVHM TWTKDKLLTE RNRNRECNAN VAVRDLFNMK
PNQTNVRRMH TAVKLNEVVV NKSQGAHLVL LNMPGPPRNR GGDENYMEFL EVLLEGLNRV
LLVRGGGREV ITIYS
//
