ID A0A3P9CLG3_9CICH Unreviewed; 849 AA.
AC A0A3P9CLG3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005023183.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005023183.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005023183.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR AlphaFoldDB; A0A3P9CLG3; -.
DR STRING; 106582.ENSMZEP00005023183; -.
DR Ensembl; ENSMZET00005023944.1; ENSMZEP00005023183.1; ENSMZEG00005017354.1.
DR GeneTree; ENSGT00950000182881; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000265160; LG12.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 577..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 642..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 779..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 849 AA; 97814 MW; 499EDC872ED31070 CRC64;
MASLLRGEEM CLAQLFLQSG SAYDCISELG ELGLAEFRDL NPTVNAFQRK YVNEIKKCEE
MERILGYLLR EIKKADISLP ETDVNPAAPL PKHVMTIMEQ LQRLEMELGE VTRNKEKLQR
NLLELTEYTH MLRITRNFVQ RNAEREPLQV QYEEFPFLEK DTLMDYSSMQ RLGAKLGFIS
GLIQRVKIEA FERMLWRVCK GYTILSYAEV EEYLEDPDTG EPTKSVVFLI SYWGDQIGQK
VKKICDCYHC HLYPYPSNNE ERDDVVEGLR TRIQDLKTVL HRTEDYLRQV LIKASESVYI
WVVQVKKMKA IYYVLNLCSF DVTNKCLIAE VWCPVSDIPA LRRALEDGSR KSGATVPSFV
NRIPTTDTPP TLIRTNKFTS GFQNIVDSYG VGSYREVNPA PFTIITFPFL FAVMFGDLGH
GVLMALFAFW MVLYENHRKF KNTRNEILNT FFEGRYIILM MGLFSIYTGL IYNDCFSKSL
NIFGSGWSVL PMFKDKWNNS VLCKNCQLTL DPHTPGVFKG PYPLGIDPIW NLATNRLTFL
NSYKMKMSVI FGVIHMSFGV ILSTYNHLYF RKKYNLYLVF IPELVFMLSL FGYLVFMIFY
KWLAFSSVDS KNAPSILIHF INMFIMQDDS SLKPLYPGQN GLQIFLVIIA VLSVPVLLLG
KPIYLYWLKN GSHRLVMYRG YERVRRSSDE DLCLMRAHDM EEGSSHSDLS TSGDHHSEEF
DFAEEILHQS IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWAMVMR IGLRMDTKLG
VVVLVPLFGL FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGTGVK FCPFSFSLLP
SCFEQDGLL
//
