ID A0A3P9CM42_9CICH Unreviewed; 984 AA.
AC A0A3P9CM42;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Chloride voltage-gated channel 1 {ECO:0000313|Ensembl:ENSMZEP00005023395.1};
GN Name=CLCN1 {ECO:0000313|Ensembl:ENSMZEP00005023395.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005023395.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005023395.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005023395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9CM42; -.
DR SMR; A0A3P9CM42; -.
DR STRING; 106582.ENSMZEP00005023395; -.
DR Ensembl; ENSMZET00005024161.1; ENSMZEP00005023395.1; ENSMZEG00005017499.1.
DR GeneTree; ENSGT00940000157383; -.
DR Proteomes; UP000265160; LG11.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720:SF4; CHLORIDE CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 52..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 108819 MW; 75B7EA7F9C87E282 CRC64;
MISRLGAFRF IVIASVSPWL QLYGEYREQL GNFARREAAR LLTERQWRRQ AGDNTAATGR
KGHGRRHHHQ HPVTLESHHS HASSTKKPRP YSKCQDCLAR VRRYIVTKMG EDWIFLVLLG
LTMALVSWSM DYASAKSLQA YKWVHGELKG NVLLQYLAWV TYPMILVMFA SLFCHLVSPQ
AIGSGIPELK TILRGVVLKE YLTLKAFIAK VIGLTAGLGS GMPVGKEGPF VHIASICAAV
LSRFMSIFSG VYENPYGYTD ILTVGCAVGV GCCFGTPLGG VLFSIEVTST YFAVRNYWRG
YFAATFSAFI FRVLSVWNKD AVTITALFKT NFRMDFPFDL QELPAFAIIG ISCGFLGAFF
VYLNRQVVLF MRRPTALTRF LTKHRLIYPG AVTLIIATIT FPPGFGQFMA GELMPRECIN
SLFDNFTWTK ISEYPAPPGL GRSAAWLHPR VSVFIILLLF FIMKFWMSAV STTMPIPSGA
FMPVFILGAA FGRLVGEIMA TLFPNGILFD GIVYRILPGG YAVIGAAAMT GAVTHTVSTA
VICFELTGQI SHILPMMVAV ILANMVAQGL QPSLYDSIIQ VKKLPYLPEL ALGKYNIFVE
DIMVRKVRFL SSQATFRELN HLLDTTTLKT IPIVDSKESM ILLGSIERTE LQALLDWWLS
PQRRVFERGQ SSPGQASKIS WESFTFVDEE GGEESPDKVE KCDLFLTIRC CLFVSETTTP
QLTDTMSPEE VLYTIDCAAS YSTMDQQTTL IDNYNLVCAF VSLLCDWLQI KAWEEAELNK
PIDMEQIRID PSPFQLVERT SLHKTHTLFS LLGLSHAYVT SIGKLVGVVA LKELQKAIEG
STRSGVRLRP PLASFRDTSR KAKKHQPPSS TTSSPTQDRD LWGEGSRREG ELVRRESKDD
SRGKPSRGAP GCDVASSSPS TMESNSSSTS TRGAEGPAQE AASPSTSSST SPSAPASPMS
ATSPVLTLSS LQEERESEDS DEPI
//
