ID A0A3P9CMG1_9CICH Unreviewed; 832 AA.
AC A0A3P9CMG1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005023224.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005023224.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005023224.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CMG1; -.
DR Ensembl; ENSMZET00005023985.1; ENSMZEP00005023224.1; ENSMZEG00005017382.1.
DR GeneTree; ENSGT01100000263513; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 99..233
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 832 AA; 94068 MW; CBB276731A2085D9 CRC64;
MLFLCVYAES PAVCQRKLKF SLKRKFQCLF EGTAKTQNPT FLNDIYTELY ITEEGTGELS
NEHEVRQIET AVRKPARPER TITCEDIFKP SSGKDQACRT VLTKGVAGIG KTVLTQKFTL
DWAEDKANQD IQFTFPFTFR ELNLLKGTNF SLVKLFHHFF TEAKEVGLCS FEELQVVLIF
DGLDECRLPL DFQNNKILTD ARQPTSVDVL LTNLICGNLL PSARLWITTR PAAANQIPPG
YVDMVTEVRG FTDLQKEEYF RKRFGEEEQA SRIISHIKTS RSLYIMCHIP VFCWITATVL
EDVLKTRAGG ELPKTLTEMY IYFLVVQAKL WSIKYCIGAE VDPHWNPGSR EMVLSLGKLA
YEQLQKGHLI FYESDLTESG IDLRVASVYS GLFTQIFKEE RGLHQEKVFC FVHLSVQEFL
AALYVFLTLT NFGVNLFQSE TWWSNLFRDK SKLSHLFQSA VDMAVQSPNG HLDLFLRFLL
GLSLPTNLTL LGGLVTQKGN ISLGKQETIE YIKSVIRRSL SPERSINLFH CLNELNDHSL
VEEIQQYLNS GTLSPDELSP AQWSALVFIL LSSEEDLDMF DLKKYSASDE GLLSLMTYWQ
LIQLQLHSLV VLFWRNAHFN YHEILSLCSR VSISVDFFVV INIAPFCMNN KRRLSGCNLT
ERCCEGLASV FSAQSSTLRD VDLTNNNLQD SGLKLVSSGL KNPQCSLEKL RLSRTGLTEQ
CCQGLSSALC TKVSSLRVLD LSDNDLQSSG VKLLCEGLGS PHCQLQTLRL TQTNLTEKCC
NDISTILSSQ YSSLRDLDLS NNDLQDSGVT FLSAGLHSPY CILKTLRSDF NL
//
