ID A0A3P9CNP6_9CICH Unreviewed; 417 AA.
AC A0A3P9CNP6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ras association domain-containing protein 8 {ECO:0000313|Ensembl:ENSMZEP00005023968.1};
GN Name=RASSF8 {ECO:0000313|Ensembl:ENSMZEP00005023968.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005023968.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005023968.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005023968.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CNP6; -.
DR Ensembl; ENSMZET00005024755.1; ENSMZEP00005023968.1; ENSMZEG00005017923.1.
DR GeneTree; ENSGT00950000182839; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16134; RA_RASSF8; 1.
DR InterPro; IPR033593; N-RASSF.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR048945; RASSF8/10_RA.
DR InterPro; IPR048944; RASSF8_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15286:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 8-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR15286; RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF21712; ASPP1-2_RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 1..82
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 81..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..197
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 228..265
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 290..352
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 115..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47383 MW; 96A6B71C1BEEE5E3 CRC64;
MELKVWVDGV QRVVCGVTEA TTCQEVVIAL AQAIGRTGRY TLVEKWRDTE RHLAPHESPV
ASLNTWGQYA GDVQLILHRT GPSLTERPPS EGPPLRGAER GLHRQSLPPL AKLRHPNDRS
LRRREPRRKS LTFTGAPRSL REILSGGRIG EAEAKRSLWA CRMEDLVRLV GLQRETLNVL
EKKLEAYEAE LQVWAEGRGG RGLIEEILRL EKYLRKNEVE MEEEEFWATE LQIELESERQ
LEERLQELRG HLQSCELEIE EKLAMVQGVE AGLEEEKLQR ERQETQWVSE AEARAQVLRI
KSELKAQERQ AVQLESSCKA VDRSLGQSSK KLQDMQHDLE QLTKELRQVN LQQFIKQTGT
KVTVLPAEPA EEGSTHNNLV PLSGSLKRPV STHPMPNHLR ALHSPLSSGL NPEGIYV
//
