ID A0A3P9CP21_9CICH Unreviewed; 1460 AA.
AC A0A3P9CP21;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Lymphoid-restricted membrane protein {ECO:0000313|Ensembl:ENSMZEP00005024090.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005024090.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005024090.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005024090.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMZET00005024879.1; ENSMZEP00005024090.1; ENSMZEG00005018015.1.
DR GeneTree; ENSGT00530000063722; -.
DR Proteomes; UP000265160; LG17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028168; KASH5_coiled-coil.
DR InterPro; IPR039508; KASH5_EF-hand-like_dom.
DR InterPro; IPR008677; MRVI1.
DR PANTHER; PTHR15352:SF3; INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR ASSOCIATED 2-RELATED; 1.
DR PANTHER; PTHR15352; LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1; 1.
DR Pfam; PF14658; EF-hand_9; 1.
DR Pfam; PF14662; KASH_CCD; 1.
DR Pfam; PF05781; MRVI1; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1402..1423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..311
FT /note="Protein KASH5 EF-hand-like"
FT /evidence="ECO:0000259|Pfam:PF14658"
FT DOMAIN 365..553
FT /note="KASH5-like coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF14662"
FT REGION 70..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 716..743
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 789..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1362..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1460 AA; 161928 MW; 1E9453F5FD89151A CRC64;
MDYCTPQPSR RHNPVDSICR KLQTIQWRGD REPNSPFQIP KLSSNSYDSP QCGLRHNLEA
ILKKGTLHRD NREKEKTREM GMPSRAASQH SSVLLTTPST PTCNRSTPAN VTYTITSTLG
ERRCADGSDL RQVKTWQGYC STPTGQSKDS PYFTFTRGPQ SAQPDSERPS RSPPLSRNFT
QSRSTLSYNV NFSSADNTNP AECELPYPAL VVKRLSMGDG GPSVASEKGK ENMAEISLIC
EENLLDTIFH ACDTQRRGKV YVSHIVDYLR HTTSRSSEDS GLEELCNMLD PEHKDVSIDL
DTYHAVMREW IDDCRNNGER PTEDDITQES VKLRDSLCAR RSMLFNVTSG SLEAFGGEAS
RVEFETSELV YCVADLQMSN QKLQEEVKKL KQVVESMEES NQKLAEENEE LHNQAKINQQ
LAQKEKMLKE EVEEMKATLS CTEEGRARAS AHSKHVAREN QSLIAKIASL QEENFKVTME
TDELQRRITE LCDINADLQM QIHSFDAVIS EKDAVIVEKS RQIDELKAAV EEYSSITELL
RVDKNKLERQ MQMILPDLAG ASLSLSVAYR MNQSSSGSLQ TELALAQSPL EAPHGVDYLS
TTSFASPLDE TLDREVLLML QGPSPEHMAL EFKNLINKLK RDFRKETDSV LTSVRVLLDD
HTQTEGDTSL QTVQAELDAR RADWVLSLDQ LAQYTDSLEK ELIKMAGNMR RSRTEILHLS
VRVQEQENQK RQLCEELEQL KTPQDSREAS CQTPALEEEV GDDLDWDEEF AIQDFLKNEL
AERNCQVHDG QREERLEETG DKITDRGEEE DAEERWTVVD SGGEGDVRDT STPLSVVTVE
AQSGQGTVGE GRGSAACSES EPEVTCQPLQ EDAVVPLSSH SQAVSVTQPE ADALPDLPHS
ENNGAEACEN GQSDSCGPAE TLRNSPDQNQ TITPVSTPPT AADMVFPNST SPGSDETISQ
TESQPTSVDH EGEEKRGKVD STAGDMSYIK SLSQDQSASR SPAEDSTSLL PVLVEEEETV
QDGAAGVPKA EPSTAGTGRL ISSKLTTLSD SSPPQSASSV THTSQSGSGM ASTVSGPSHS
EELTRTVEAV KEHKVQEDQN VASMATDTET EMLVIPDTFK DKNNLSPSDK EIEAEFQRLA
LGFKCDMFTL EKRLRLEERS RDLAEENVRK EVSSCQGLLQ ALSPLCDNDN QSMEIIQRLQ
KNLDILIQSM TRVSSRSEML GAIHQESRIG KAVEVMIQHV ENLRRLYTKE HAELLELRET
LMQNERSFGS QTEKDDFRER RKQSSQYNKT ARRSSMITIS RAGPGNMHFD TSKTQDGSEV
ESERLTRRSP WNVAGKITAR PPLKRFSSSV PWVDTEEPSL VMKGPSPSSS PTSTEPGAAQ
SLSHSLTSSR TAAAVARGGR GLWLWLAMMV LLAGLLALLA SLVMQPAVDA APVGTGDSWM
TIQQLLWPYT GLRYNGQPPV
//
