ID A0A3P9CWG9_9CICH Unreviewed; 815 AA.
AC A0A3P9CWG9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Protocadherin 18a {ECO:0000313|Ensembl:ENSMZEP00005026683.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005026683.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005026683.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005026683.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9CWG9; -.
DR Ensembl; ENSMZET00005027540.1; ENSMZEP00005026683.1; ENSMZEG00005019896.1.
DR GeneTree; ENSGT00940000156295; -.
DR Proteomes; UP000265160; LG18.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF9; PROTOCADHERIN-18; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..815
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018287793"
FT DOMAIN 35..131
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 132..240
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 241..348
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 364..460
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 461..570
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 591..688
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 716..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..754
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 90612 MW; B3FA80A0F7DF8641 CRC64;
PRQMETKMKG LLLPRMWKVL AVLALATQHI TGKTLKYQIY EEQKVGTVIA RLKEDITDVL
AKLPSSVSSF FNVREQDGEI SIKTKIDREK LCEKNLNCSI QFDVVTLPTE HLQRFLIKVE
VLDINDNAPQ FARAIIPIEI SESTAVGARI PLDSATDPDV GENSLYSYAL EPNNFFKLVI
QSRTDGVKYA ELVVLRELDR EECSGYGLQY TASDRGIPLR TGSTLLKISV TDSNDNSPLF
ERSLYVINLP ENSPVGTLLI DLNAMDADEG TNAKIVYSFS SHVSPKIMET FKINPDNGNL
TLIRRVDHET ANSYDIDVQA QDMGPNSMPA HCKILVKVVD VNDNKPDISI TLGSFQGNGD
AAYVSEASLL DTFVALVRVE DLDSGLNGEV ECKLHGQGYF KLQKTYENNY MILTNVTLDR
EKRSEFSLTV VAEDRGTPSL STVKHFTVHV TDENDNPPRF EKGQYEIFKS ENNAPGVYLT
SILATDPDLD SNGQVSYSIL ENAVHGSSIS TYVTIDPSNG AIYALRTFDR EDVSRIAFIV
QAKDAGKPAL LSNAAVILNI LDENDNPPVI VVPQLCNFTA DVPASNFTEA GHLITVVRAT
DRDTGVNAEL ICSIVSGNEE GFFLIEPRTC EIHANASLDN VPHDYAELTV VVRDQGSESL
SAKAILKITL HETIENHGSV TDQGEPSLDV SLIIINSLRA ICVALMHSYS CRVAESTHQH
HPKKPSHQIH THTHTHTHTH THTHTHTHTH THTHTHTHTL SDFPINEIPE IIHIVVFQDL
RKLVMINNNN PLICNFKKTF MVQKKVKKQN MKSYL
//
