ID A0A3P9CXA5_9CICH Unreviewed; 894 AA.
AC A0A3P9CXA5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=DEAD/H-box helicase 11 {ECO:0000313|Ensembl:ENSMZEP00005026973.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005026973.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005026973.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005026973.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR AlphaFoldDB; A0A3P9CXA5; -.
DR STRING; 106582.ENSMZEP00005026973; -.
DR Ensembl; ENSMZET00005027838.1; ENSMZEP00005026973.1; ENSMZEG00005020109.1.
DR GeneTree; ENSGT00950000182970; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:1990700; P:nucleolar chromatin organization; IEA:Ensembl.
DR GO; GO:1901836; P:regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0009303; P:rRNA transcription; IEA:Ensembl.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 4..424
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 894 AA; 100587 MW; A4B6F4055E2CEE7F CRC64;
MENSRAQFPF PYQPYNIQEE FMQALYSALD KGKVGIFESP TGTGKSLSLI CGALSWLTDY
EERKRQEAAA LLQEGEAALS TNAAQSSAVS SSAELDWITD FVQKKAEHDL VSKLKEEELK
RKKREERLEM IRNNVQLKYA VKRKSYEEDE AFKLLQLSKE EQVEATGDQE DEELIIAEYE
SDDESKIKSR FFGAEKDEDD ELVEEHVTKI YYCSRTHSQL AQFVHEVQKS PFSKDISVVT
LGSRQNLCIN EEVRQLGSIQ RINDRCMEMQ KNKHEKHHHE EGVKRKRGPA KSVCPYNKAS
ALQQMRDVVL GAVHDIEQLL KLGRETHSCP YYSTRLAIPP AQLVVLPYQM VLHEATRRAA
GVQLKGQVLI IDEAHNLSDT LSCIHSAELS GAQLCCAHSQ LSQYADRYKS RLKAKNLMYI
KQILFVIEGL VRVLGGKVGQ SPQSQTTQPG TEMLTINNFL FKAQIDNINL FKLQRYFEKS
MISRKLGGFV EKYAGSGVTL HTHCNNKENR RTEGLNRYLQ TLQSNQNPGT VPSADQQESV
ETEKVLSASP MMQVEGFFMA LTNSNTDGRV VVHKQGSLSE SSVKFLLLNP AVHFAQVLEE
CRAVIIAGGT MQPVSDFKQE LLFSAGVGEE RITEFSCGHV IPPENILPLV LCSGPSGQEL
EFTFQNRDTP RMMDETGRIL SNICNVVPGG VVCFFPSYDY SKRIISHWEA SGTLTRLANK
KKIFQEPKKA NQVEQVLNEF SRCIQRCSAD CSGLTGALLF SVVGGKMSEG INFSDDLGRC
VVMVGMPYPN IKSPELQEKM SYLDKHLPHS QGRSPGQALI ENICMKAVNQ SIGRAIRHRG
DYSSVVLCDR RYSRPATLSK LPTWIKDRTT THTTFGPAFA ALRKFFLEKK QKKA
//
