ID A0A3P9CZ63_9CICH Unreviewed; 432 AA.
AC A0A3P9CZ63;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=5-hydroxytryptamine receptor 2A {ECO:0000256|RuleBase:RU368060};
DE Short=5-HT-2 {ECO:0000256|RuleBase:RU368060};
DE AltName: Full=Serotonin receptor 2A {ECO:0000256|RuleBase:RU368060};
GN Name=HTR2A {ECO:0000313|Ensembl:ENSMZEP00005027384.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005027384.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005027384.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005027384.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
CC (serotonin). {ECO:0000256|RuleBase:RU368060}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368060};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU368060}. Cell
CC projection, dendrite {ECO:0000256|RuleBase:RU368060}. Cell projection,
CC axon {ECO:0000256|RuleBase:RU368060}. Cytoplasmic vesicle
CC {ECO:0000256|RuleBase:RU368060}. Membrane, caveola
CC {ECO:0000256|RuleBase:RU368060}. Presynapse
CC {ECO:0000256|RuleBase:RU368060}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU368060}.
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DR AlphaFoldDB; A0A3P9CZ63; -.
DR Ensembl; ENSMZET00005028257.1; ENSMZEP00005027384.1; ENSMZEG00005020424.1.
DR GeneTree; ENSGT01050000244937; -.
DR Proteomes; UP000265160; LG16.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-UniRule.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF30; 5-HYDROXYTRYPTAMINE RECEPTOR 2A; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Cell membrane {ECO:0000256|RuleBase:RU368060};
KW Cell projection {ECO:0000256|RuleBase:RU368060};
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU368060};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368060};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Synapse {ECO:0000256|RuleBase:RU368060};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368060}.
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 304..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT DOMAIN 101..361
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 432 AA; 48001 MW; FD78F3E9FB599758 CRC64;
MWPLAPFVPE TRSPVHPLLA SFVHCLCPAA RGLILHWTLL PVFPLLGSHS HLDRDRSLLK
GCSFRCSAET PFGFSRSRCS VSMGFPKISC PIGVPNSHYG WPLPSDLCPI WIYLDVLFST
ASIMHLCAIS LDRYIAIRNP IHHSRFNSHT KARIKIMAVW TISVGISMPI PVLGLRDHSK
VFKDGSCLLT DNNFVLVGSF VAFFIPLTIM VVTYFLTINA LQNEATLCLD QLVPRPKWST
TFTLSFFPQT SLSSEKLLRR SISRDATGRG STGGLGGARG SISGSLFGRR TMQSISNEQK
ASKVLGVVFF LFVVMWCPFF ITNVLVVVCE PDVCDPGVMG GLLNVFVWVG YLSSAVNPLV
YTLFNKTYRA AFLRYVRCQY QPEKKPLQLI LVNTIPPLAY SSTQSGEQGS LLFQNLLYTA
AKDKITLDKH IN
//
