ID A0A3P9D0N3_9CICH Unreviewed; 855 AA.
AC A0A3P9D0N3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005028148.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005028148.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005028148.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9D0N3; -.
DR Ensembl; ENSMZET00005029044.1; ENSMZEP00005028148.1; ENSMZEG00005019459.1.
DR GeneTree; ENSGT01070000253760; -.
DR Proteomes; UP000265160; LG17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 64..198
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 855 AA; 97090 MW; 1723233C2FCFA94E CRC64;
RRSNLSGSDI NQLLDKHKAN LERRCKCLTE ETGSGTLFNR IFTELYITEG QSEEVHTQHE
RCIRVVLTNG IAGIGKTFSV QKFTLDWAEG LENQRVSVVI LLSFRELNLI RDDRYSLLDL
LHVFHPTLQK VTAEQLTVCK PLFIFDGLDE SRLSLDFTKG KLVSDVTQKS SVSELLTNLI
KGNLLPSALI WITSRPAAAN QIPPICVDRV TEVRGFTDAQ KEEYFRRRFS DEEVSSKFIS
HMKTSRSLHV MCRIPVFCWI TATVLEHMLT TEQRGELPKT LTDMYSHFLL VQTKRQHKYH
EGYETSPQEL TEADSEVLLK LGRLAFENLE KGNIMFYQED LEQCGLDVTE ASVYSGVCTE
IFKRDCVIFQ KSVYCFVHLS IQEFLAAVYM FHCHTNRKTE VLKHFLGNGE HVYCGDISSL
DVFLSRVMQK SLQIKNGHLD LLVRFLYGLS LESNQRLLRG LLGETESTPE IIQRIISNLC
KITNENTSPD RCINIFHCLM EMNELTVHQE ILEFLKCKNG SEKELSEIHC SALAYMLQMS
EVLDEFVLKK YNTSDEGRRR LIPVLFRFYW YYLNSASGCT SYTSLGLCKH SVCRCLERAD
INLSLSGFSL HHCALFLLFN NILLWNMPHK TLVLYNNLFC NMCHHRLSGC KLSETHYAIV
ASALMSNPSH LTELNLNGNN LQGLESKNLF AALESPNCRL ETLRLELCSF SEIGCASLVS
ALKSNPSHLK HLDLGGNAIQ DSGVKQLCGF LEIPLCRLET LMSVCLLSAI TKSYNLCGKY
GLCANLKTVH MCLWCCSLSE ISCATLVSAL RANPSNLKYL DLGVNKLQDS GVKHLCGFLE
IPLCRLETLR SVHFL
//
