ID A0A3P9D1E4_9CICH Unreviewed; 897 AA.
AC A0A3P9D1E4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Actinin alpha 3 {ECO:0000313|Ensembl:ENSMZEP00005027926.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005027926.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005027926.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005027926.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004570725.1; XM_004570668.2.
DR AlphaFoldDB; A0A3P9D1E4; -.
DR STRING; 106582.ENSMZEP00005027926; -.
DR Ensembl; ENSMZET00005028816.1; ENSMZEP00005027926.1; ENSMZEG00005020827.1.
DR GeneID; 101479518; -.
DR KEGG; mze:101479518; -.
DR CTD; 323320; -.
DR GeneTree; ENSGT00940000153968; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000265160; LG3.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF432; ALPHA-ACTININ-3; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 41..145
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 154..260
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 756..791
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 792..827
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 275..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 440..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 674..701
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 897 AA; 103866 MW; ED5F9C80BAE5D949 CRC64;
MTAVETQITY TNSYTIQHED AYMTQEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT
QIENIEEDFR NGLKLMLLLE VISGERLPKP DKGKMRFHKI ANVNKALDFI CSKGVKLVSI
GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YRNVNVQNFH
ISWKDGLALC ALIHRHRPDL IDYSKLRKDD PIGNLNTAFE VAEKYLDIPK MLDAEDIVNT
PKPDEKAIMT YVSCFYHAFA GAEQAETAAN RICKVLAVNQ ENEKLMEEYE KLASELLEWI
RRTIPWLENR VAEQTMRAMQ QKLEDFRDYR RVHKPPRVQE KCQLEINFNT LQTKLRLSNR
PAFMPSEGKM VSDIANAWKG LEQVEKGYEE WLLTEIRRLE RLDHLAEKFK QKCAMHEAWT
TGKEDLLSQK DYESASLMEI RALMRKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYHDAA
TVNTRCQGIC DQWDNLGTLT QKRRDSLERV EKLWETIDQL YLEFAKRAAP FNNWMDGAME
DLQDMFIVHS IEEIQSLITA HDQFKATLPE ADKERMATLG IHNEILKIAQ TYGIKLSGIN
PYTNLSSQDI STKWDTVKHL VPLRDQMLQE EVARQQANER LRRQFAAQAN IIGPWIQTKM
EEISHVSVDI AGSLEEQMNS LKQYEQNIIN YKSNIDKLEG DHQLIQESLI FDNKHTNYTM
EHIRVGWEQL LTTIARTINE VENQILTRDA KGISQEQLNE FRASFNHFDR KRNGMMDPDD
FRACLISMGY DLGEVEFARI MTLVDPNNTG VVTFQAFIDF MTRETAETDT AEQVMASFKI
LASDKNYITV EELRRELPPE QAEYCITRMT RYVGPDCPSG ALDYISFSSA LYGESDL
//
