ID A0A3P9D1G3_9CICH Unreviewed; 1094 AA.
AC A0A3P9D1G3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSMZEP00005028433.1};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSMZEP00005028433.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005028433.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005028433.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9D1G3; -.
DR STRING; 106582.ENSMZEP00005028433; -.
DR Ensembl; ENSMZET00005029337.1; ENSMZEP00005028433.1; ENSMZEG00005021201.1.
DR GeneTree; ENSGT00940000157711; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 23..75
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 80..199
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 135..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 205..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 802..836
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 112195 MW; C2025954DF4EF6D9 CRC64;
MVSGERCLAA DDEFLTSNMK EMIGGCCVCS DERGWAENPL VYCDGHGCNV AVHQACYGIV
QVPTGPWFCR KCESQERAAR VRCELCPHKD GALKRTDNGG WAHVVCALYI PEVEFANVST
MEPIVLQSVP HERYNKTCYI CEDQGRESKA ATGACMTCNK HGCRQAFHVT CAQFAGLLCE
EQGSDADNVK YCGYCKYHHS KLRRSRGRGS RSQSLSDSST QCMDRPPDTD KKKHKERDRH
KPKHKKTSMD MSPSLILPNI MVPEKTYNSG NSGGGVSSLQ ASSQKRLDDS AARFTNANFQ
EVSSAHSGSS SKDALAADSV KAATEVKNKK NSGGGHTVGP RGGRKSLTSS GKPLPSAVVT
MATSSTSASA STGPFHQGLL LTSASKTPSA ASSSDFLSFT DSSLRPGGGS TFSSPPSFSS
CLVKPGSEGG ASEGTTTLFG SLMSATTASA VGGKLYENSH SHTVSETTSL VGSTGYKRPQ
PSSSGLGISG AAAGGGEDGV KKKKKGNWRN RFGPCFTTDV KPSEPAPSLT LPTTSTANTT
SSSTASPSSS SSSTLSGRPC LVSSSGLGVG VGGGSGGGER GLGVMGVSGG IQKSPSLLRN
GSLQSNSSST TTGSGVFSVA DGSSSGTGAV TMGGANSELS QQQQPTPSLA PPSPFTATAP
LNSTASTHVS ALPGSVFNLA PPHMFGNRLN PNSTMAALIA QSEASPADQE AGDGSNSGGG
CVGAQGFSIR ASPKTTPRSP IGGLQIRYDS SGSLPGPGQG LLGAGGGGET LPPVATSIEQ
LLERQWNEGQ SFLLQQGAQG DVVSMLKSLH QLQEENRRLE EQIKTLTMKK ERLQLLSAQL
SVPFTPATAS SDVKGAQPGA ADSSLPVATQ DSASCGGHSS SGSTSSLSTP PSVSQSPPQP
QLNGVASVGV TPAGLGGVAG LMGALGAGSA LGMGGIVGAL NGVIQTPAGT SSPHTHTTGA
ATGVTLPVNN NATRIGLLSE QQRLLLQQHQ LHQLLSSQPS VEQQQVLLYQ LMQQQDLQQL
QSLSSSAQIP SIPLSSAQLP INNLLPGAQS QGQGTITANP FLALQHAHAD THGSGAQKPR
LAEKAVGVGG QEKT
//
