ID A0A3P9D2K2_9CICH Unreviewed; 3689 AA.
AC A0A3P9D2K2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protein bassoon {ECO:0000313|Ensembl:ENSMZEP00005028584.1};
GN Name=BSN {ECO:0000313|Ensembl:ENSMZEP00005028584.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005028584.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005028584.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005028584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic active zone
CC {ECO:0000256|ARBA:ARBA00034101}.
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DR STRING; 106582.ENSMZEP00005028584; -.
DR Ensembl; ENSMZET00005029489.1; ENSMZEP00005028584.1; ENSMZEG00005021314.1.
DR GeneTree; ENSGT00620000087961; -.
DR Proteomes; UP000265160; LG20.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0048786; C:presynaptic active zone; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15772; FYVE2_BSN_PCLO; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR008899; Znf_piccolo.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14113; PICCOLO/BASSOON; 1.
DR PANTHER; PTHR14113:SF14; PROTEIN BASSOON ISOFORM X1; 1.
DR Pfam; PF05715; zf-piccolo; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 130..187
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT DOMAIN 398..455
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT REGION 50..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2383..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2632..2686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2862..2934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3045..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3263..3315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3380..3595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1611..1652
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2161..2275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2754..2798
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 73..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..236
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..710
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2404..2427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2436..2461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2512..2572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2872..2893
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2894..2911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2913..2929
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3055..3073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3263..3290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3405..3432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3433..3447
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3448..3475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3476..3558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3689 AA; 403365 MW; CF8DD27A9A9A8970 CRC64;
MQQGGHGGRG MGGGGMGGMG GGGMGGMGGG GMGGMGGGGM GGMGGGGMGG MGGGPGSGQG
MGHGPAGSSM GGHGGQSPGQ HASRRNLQVD FSGSGGSRTG RSPSLSPDRG VTPTSPYSVP
QIAPMPSSKL CPVCTTTELS NPPAVPNYNT CTQCKATVCN QCGFNPNPHL TEVQEWLCLN
CQMQRALGID MTTPRSKSQQ QIHSPSHQAK PIVQPQQPAP QPTHQPGGPR IPHPGAVPLP
GLTKAPSQPD LGRGSPMHQS MARHDQTRSA GSSPAHRPQS QAPPAQDGLT KLFGFGASLL
NQASTLINVD PLPTASTQPS PARGKVVFSN ATPDNRQQQQ GTTSTKPFTM GGPHAPSQMG
GPNQQQKTPT HQQKVQQKQE PVAAAPVVAP EPVKPKVNCP LCKTELNISS SDPPNYNTCT
QCHSQVCNLC GFNPTPHLLE KKEWLCLNCQ TQRLMSGEGL DEPPLPVPHP SPKHQPTGSP
RHQTPISQQS PLHKPTTQQG TKPGQPQTQS QKPQAGSVDT KNNSTHDLSR SPQSLSDTGY
SSDGISSSHS EITGLIQEEE MKLSERGISS RGSPPSPSEI TKLESSMRPL LEKSFSEEKA
DRRGRKHRDR DLDDRGKQRP RSLSIPPDAY DSDEELEDIL EEEEDGGDWE GKRKEGKEEK
KEKKKKEKEA EPTEMTDEEF MRRQIMEMSA DEDNEEEEEE MEEDEDEEDE GYGYQKPKKS
HHKHIISDSG KEKRRLQHHS SSFEEETKSS TDVYKGSLEE GEEDVMASQG GLRRFKTIEL
NNTNSYSRDI ELSNENDLSL DREPELEMES LTGSPEERSR GDYSSTLPPT SSSYGSGQSP
TSISSMEEDS DSSPSRRQRL EEAKQQRKAR HRSHGPLLPT IEDSSEEDEL REEEELLREQ
EKMREVEQQR IRSTARKTKR DKEELRAQRR RERSKTPPSN LSPIEDASPT EELRQAAEME
ELHRSSASEY SPQSLDSEAE GYESKLYKSG SEYNLPTFMS LYSPIEKTTA TTTTAPSSTS
KPLKSAEEVY EEMMRKAEML QKQQKQQQQQ QQHGRHGQYY EEDINGQSYD DEYEYEQDQT
GYDNEAAETE TDIYEEIRQT SQNITKMQQA TDEQVEIEIE SSYPDKQLLD TGSAFAKLLE
QSNALLTPGT SPTQISAPVS FAETAGRIPD VRVTQHYSAK DGHKDRLKTQ AGKNGITPTV
AATTIAAYGV YARDAVTISQ TGSSHTVTST QSEIGRRHMG STSASSATVS SVCSKIAEIT
QAYSQREVIT RRVGETRGIQ VRDSSTSSIE RIIEPRSPKY TTYYRSTSPP LSPSPPPPQS
PTRSPSRRAT AEFSTQTFSS ALRMESAGSG PTSPVMAQGT QTSHRSVSPR LYRQQSSQDA
PYSPPSSPAR PTTVNTATSP LSSPTRFSRQ STFDTYSPCG SPPDTPPYHH SPTRSFYRTQ
RVEKVNVGTS MVTTASIYTR GSVSMDNISL CRISTVPGTS RVEQGHMIHG GSVVDLRTAT
KPAPIIMTDQ GMDLTSLATE SRKYHGGPEG SRHSTIVQPL IMNLNTQETT TPTTVSVTVA
ASMFMTQPKQ PTVYGDPHQN RVDLGQGMGS AVCLSQNKPV SPPTDPSIPK IDAKLEDLSI
QQRELQKQQE KLQKQQELLE QQLQHHHQMQ QQQQQASVLA RYNLTGPISP LLKKDLLVSQ
TTTASAVVSA VSPIINPELY GAGPVELKGK PSPPGLISGG KSPHSMVVQM DGGPDPARAV
TQLVKVEEGQ DAVDLTGGQI KPDNQPACCD IVYRLPFGGT CVGAPEKEGI RPPSAPPLTY
ESDQERQPGR YHEYPMDGRK AYTLPFPGRL QPSMSDTNLA EAGLQSYHSK VEPHLQASGE
LAMDLTAMKQ GYGGYVGMQY GSYTDLRHGG DIAAQTLPIR RYNSLSNISS DYGYSARDIA
NFQEANLAQY SATTAREISR MCAALNSMDR YGSNPDLMQF GSLSRGTGPM ASRLAAGLGI
RQNLLFGLDG KPISHSQALT NLINARQASL RAMYPAAIRS SDGMIYSTIQ TPIASTLPIT
TQPASVLRPL IRGVYRPYLS ANMTPVPLSS LSRLPMSPRM PLSGQAAVRY PAPGTVVIPP
QQPAPAAHAY PLSGPAQTHG YTQPPAVLSA PTAGLPIPGG LPPFPPPGAI HKEGETEAER
LHRQQEQLLQ MERERVELEK LRQLRLQEEL ERERLELKLH REKEQMLVQR ELQELQNIKE
QVLQQQQHER EKQLVLQREQ LAQQKSQLDQ IQSLQQQLQQ QLEEQKRQKT AAVTQIMQVG
VGAATQPCRS DLNHCFIAIL KPHGFFVQLD GQPLHPYADS HMGSRSLPNS SSEMCLRSQE
EQMEARTNMR KHSSMSRLTR DSLDGDGVVF YGSPRRIVDS CVQTDDEDGE ERYMMRHRTR
RRGRSVDCSV QTDDDEDKAE TEHPVRRRRS RFSRHSESSA AGSSTATTAT LATDTKTDKT
KMVSSNIGVQ TIREMSCQTE VEHLGRVSPA IHVTVPDPNK VEIVHYISGP ERTQKGQSLA
CQTDPEAQSQ GVVAPQLSVP TTVSPYSSSA GTGTQQSGSD LLTQQRQQQI AANAAKFERR
RPDPLDINYQ PHNHLHNESI SSIIRQQQTA PKSPQVLYSP VSPVSPHRLI ETSLSSERLN
KAHVTPQQKS YTAESPQRHP SVPRPIKSTQ RSMSDPKSLS PTTDEHTKAR LSLYQQQALQ
NQVNSLLRKV KRTLPSPPPD ETVTSAHLPM MTPALQQVYL PSVPSLKPSS RSGLAAKASL
LKDLTHELKA VEQESTKLRK QQAELEEEEK EIDAKLRYLE LGIHQRKETL VKERERRDIA
YLRCMGDTRD YMSDSELNNL RLAAFTSDLN TAAQYPPTSS FLSCQYPQSQ PAALPQPTPL
QTHAPPPGPT YQPQTSYPSH TYPQTQPPYP QTDMGLPAAP QPQPHQTTPY PGQPQVDILT
VHPGRPRQTS LADLEHKMPT NYETISNPTV VVTTTAQDAT YSSGAPSYAH SYGQYTTTTA
NTYADGMYGA PGLEQNIPRN YMMIDDVSEL TAKDGLGTMT GDMMHHGGSG RYPGDIHSHS
STTGTTRGGT GSSSYGRAPE EEAAMQEELY DHHGRGKSSY RHGPLGGSSS ASMGGGSPYF
YDFDYKHGSI RSGVQKPSPS SRTLLAPAVM SSKRSKHRKL GSMEQKISKF SPIEEARDVE
ADLASYSSVT GAAYPSSHIR GRQLIEDYGF KRSAYDSGSG TTHGSRYYSM TVDEDDRIYY
TSTGRSRSTG YGMDKISARD YSGYRSRSYE RDDRSYRSGY RGRHPTRQYS EEESPLSPLG
RFMGSGRSSS LGPDPYDSHS GRCKYYYGHY GSSHSLPDVQ DHIRDLPRTH VYKSDDTYFI
DDYHCAVSDS EAYHLGQEET DWFEKPRSSS RHYGSSHSGR SRHSVKHTYH DYDEPPEEDL
WPQDEYGHTG RHSSSRDHRH HGSSSRHSSS SRHSDEPRSS RSSKGHPKDP SMRHDPSGRS
SSTGRRSSRS GSGSARAQGS AGGPTGSGRQ GGPGSQTDGA PGQRAQLQQQ AQTSATRPGQ
PGATTTNSSQ QQPQAQGQGM GMGMGMGMGQ GQAKPGQMGP AGGPMGQARQ TGPTGTTTST
IVIFFRIFVS GHVSSPTSHH PLPFFHSLYF CPGSKAAPRP GGIGSAAAGQ PGMEGEGMFS
KILPGGAAEQ AGKLGEAISG FGKKFTSFF
//
