ID   A0A3P9D2T4_9CICH        Unreviewed;      1030 AA.
AC   A0A3P9D2T4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Semaphorin 5A {ECO:0000313|Ensembl:ENSMZEP00005028664.1};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005028664.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005028664.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   AlphaFoldDB; A0A3P9D2T4; -.
DR   Ensembl; ENSMZET00005029569.1; ENSMZEP00005028664.1; ENSMZEG00005021366.1.
DR   GeneTree; ENSGT00940000158036; -.
DR   Proteomes; UP000265160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF78; SEMAPHORIN-5A; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00209; TSP1; 6.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS51004; SEMA; 1.
DR   PROSITE; PS50092; TSP1; 6.
PE   4: Predicted;
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        924..946
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..447
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
SQ   SEQUENCE   1030 AA;  115589 MW;  AA5D8DD40B7A1A57 CRC64;
     QRCFNWPFGD VSFKFKPWIF RFKAEGTVDY SQLTFDPGQN ELIVGASFSF SLQEAEWHCD
     EFTKGACFSR GKSEEECQNY IRVLLVNGNR LFTCGTNAFT PICTNRTLTN LTEIHDQISG
     MARCPYNPLH NSTALITSSG ELYAATAMDF SGRDPAIYRS LGGLPPLRTA QYNSKWLNEP
     NFVSSYDIGN FTYFFFRENA VEHDCGRTVF SRAGRVCKND IGGRFLLEDT WTTFMKARLN
     CSRPGEIPFN YNELQGTFYL PELELLYGIF TTNVNSIAAS AVCAFNLSAI SQAFNGPFKY
     QENSRSAWLP YPNPNPDFQC GTIDSGAYVN LTQRNLQDAQ KFLLMHEVIQ PVVPVPYFME
     DNVRFTHVAV DVVQGKDTLF HIIYLATDYG TIKKVLSPLN QSTGSCLLEE IELFPPRKRQ
     HIRSLLILHS RSELYVGVRD QVIKIPLKRC SYHKTCVGAR DPYCGWDLLL KKCTTLEESI
     RMSQWEQSIS KCPVRNVTVD GGFGAWSGWS TCSHNDGGSA GSCLCRTRAC DNPAPQCGGQ
     QCHGISVEVA NCSRNGAWTP WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE
     ERYCNEHLPC PPHVYWSAWS AWERCTVPCG GGIQSRRRTC ENGNDCPGCG QEYQSCNTLP
     CPDLKKTTPW TPWTPVNISD NGGHYEQRFR YTCKARIPDP SLLEVGRQRI EMRYCSSDGS
     TGCSTDGELL RLGRISSHTV NGAWSSWSSW SQCSRDCSRG IRSRKRTCSN PEPRYGGQTC
     LGPAQEYQEC NITPCPVDGS WSCWSSWSKC SVTCGGGHYM RTRTCSNPLP AYGGDICLGL
     HTEEALCNTQ PCPESWSSWS EWSHCDSSGA QLRVRHCDVL FPTGNQCLGN SSETRPCSPD
     SNFIPEVSIA RSSQEERRCG DFNLFHMIAV GLSSSILGCL VTLLVYSYCQ RYQQQSHDAT
     VIHPISAAPL NTSITNHINK LDKYDTVEAI KAFNKNNLIL EERNKYFNPQ LAGKTYTNAY
     FTDLNTYDDY
//