ID A0A3P9D729_9CICH Unreviewed; 1706 AA.
AC A0A3P9D729;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSMZEP00005030373.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005030373.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005030373.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005030373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004553145.1; XM_004553088.1.
DR RefSeq; XP_012775090.1; XM_012919636.2.
DR Ensembl; ENSMZET00005031326.1; ENSMZEP00005030373.1; ENSMZEG00005022627.1.
DR GeneID; 101467591; -.
DR CTD; 10260; -.
DR GeneTree; ENSGT00940000155836; -.
DR OrthoDB; 1079051at2759; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 42..199
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 191..640
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 814..848
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 894..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1706 AA; 188296 MW; 4F586F95967441DB CRC64;
MMEDKGPRVA DYFVVAGLTD SSKPLEEDLH FDDAGPKSVK PKAPITDVAV VIRSLGEEVP
PGFTCVETTP SGLSAELNGA SLRGPQIFLC FKRGRDKPPL TDLGVLYEWK EKLKPGCHIV
QTTPSGRPAN ISSSSSQRIY ITYRRAPKSQ PHTSLAVTDV CVIIPGKGET PPHTFCKVDK
NLNSSMWGSS VYLCYKKSLA KANTIAYKAG LLCRYPEEDY ESFPLPESVP MFCLPMGAMI
ECWPAHTKHS LPVFSTFVLT GASGEKVYGA AIQFYEPYPE ENLSERQRSQ LGLPSSDLRP
DETRNVYSNK SICLLSHWPF FQSFRSFLTF LYRYSISGPH SLPIEKHISH FMQNVPFPST
QRPRILVQLS PHDSLMLSQP VSSPLPLSGG SLSTLLLNLG PKNAATLLVL AVTEHKILVH
SLRPAVLTSV TEALVSMIFP FHWPCPYIPL CPLALADVLS APCPFIVGMD SRYFDLYVPP
ADITCVDLDT NTISQKDDKK ALTWKILPRR ACKHLLNSLN KLYQQLIEGG HLNHEDVQMD
HTVTDCELES GKSLHTLELE IQEAFLRFMA AILRGYRSYL LPITQAPSEK TTDASSLFDI
QGFLKSRDRS HQRFYSLMTK TQMFSRFIEE CSFVSDKDAS LAFFDECVDK LFSSGGKMDS
ERPEDARLIE LDESHRSEHT VYINPPELPP PSQGEEHPLC YSYSAFPVLN AELLEPLEGA
SPSSAGIASR HSSPASPTAI FRRSKQEIKS AQRMAKTYSS MPQMWSKCLL RHCYGLWFIC
LPGFVGNCHS KVRALRTAYD VLRKMQDKKL QAPDEVCYRV LLQLCGQYSQ PVLAVRVLFE
MKKAGVQPNA ITYGYYNKAV LESTWPSTTR GGYFLWGKLR NVLLGVLQFK QAGRKQRNSQ
RDPHLSDGSD LDTVSHGSLD SANDSAERTS IDTDFTKMDS SDDGFSTGEQ SDQGYDSLSK
EEERLCSRES DGTALVEDKG VKSSSGLRLA SSPSSDTLLS GALPKAERPN SLDLSGGQGT
LRLSVPILST SKQLHLASDR LHEVEEEVTE TDKQKHPVER AGVICNAGTV RRTGIEMGFD
PLSLMATATV QECDHDNSSA SNSRRNLAEE IETYMNNGNS PLSSRTPSMD LQNPSSPLFR
SASSPHSSPQ SSTLVQSTTH LPLPAKTKER LRQSPSLPLG ICNKDRERPP SLVSPSSPTP
STSSFSMETL FTPTLDIFKS SVISAGKGVA EKASRLYSRL SSQTSLTQDA NCDRMSVSSL
TSGEADCFSL LDNDSCLDPD GFTSPQHGSV SRVRRSPVGH HHTNLGSPGT PNRVFRHNSF
SGGLALPSKT PHTPDSSPDT GRFQPTPNYT VEVLMSSCSL CKTCDCLVYD EEIMAGWTAN
DSNLNSTCPF CGTAFLPFLN VEIKDLRPHS RSSKKSNPVK EEDTSLPPNP EEKISTTDGA
AEASAAPAQK RESSGGAGQG PASSSSSSCS SASAPVTVPY LSPLVLWKEL ESLLVNEGDQ
AISSPSVVDQ HPIVFWNLVW YFRRLDLPSN LPALILGSQH CSHEDQTPQM LSSEDSKQVL
VRIMWDNLKL HQDKVQPCYV LWNTHCANSL VRSGLCEEGQ LFTVELLQGF VRSIKKSDVH
QPMSQIIQLL GPELGFKRQR SLYRELLFLA LVALRKNNIN ISAFDREYKL AYDRLTPNLV
KLTHNCDRPP GAGVMECRRT FGEPGL
//
