ID A0A3P9D781_9CICH Unreviewed; 553 AA.
AC A0A3P9D781;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Lactase like {ECO:0000313|Ensembl:ENSMZEP00005030423.1};
GN Name=LCTL {ECO:0000313|Ensembl:ENSMZEP00005030423.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005030423.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005030423.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005030423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC {ECO:0000256|RuleBase:RU003690}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004553132.1; XM_004553075.3.
DR AlphaFoldDB; A0A3P9D781; -.
DR Ensembl; ENSMZET00005031380.1; ENSMZEP00005030423.1; ENSMZEG00005022665.1.
DR GeneID; 101463933; -.
DR CTD; 564250; -.
DR GeneTree; ENSGT00940000157369; -.
DR OrthoDB; 3373839at2759; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF335; LACTASE-LIKE PROTEIN; 1.
DR Pfam; PF00232; Glyco_hydro_1; 1.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..553
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017983581"
SQ SEQUENCE 553 AA; 64069 MW; 0C7B4CB70EDA433D CRC64;
MLPRCAVGVC HVLMLVLCVS AAEDFDWTKN HHGSFYYGTF PAGFSWGAGG SAYQTEGAWD
KDGKGLSIWD VFSHRKGKIQ QNDTGDFSCE GYYKVKDDIS LMKELRLNHY RFSISWPRLL
PTGIKSDHVN EKGIQYYDHL INHLLENKIT PIVTLYHWDL PQVLQEKYGG WQNISMVNYF
NEFANLCFER FGDRVKYWIT FNNPWSVAVE GYETGEHAPG LRLRGTGAYR AAHHIIKAHA
KVWHTYDTQW RGKQKGLVGI SLSGEWGEPV DISNQKDIEA AERYVQFHLG WFATPIFHGD
YPQVMKDFIG RKSVQQGLGT SRLPTFSPQE KSYIKGTCDF LGIGHFTTRY ITQKNNPSGR
SSSNYFSDRD LAELVDPRWP DPGSEWLYAV PWGFRRLLNF VKTQYGNPMI YVTANGVSEK
MLCTELCDEW RIVYYKDYIN EMLKAIKDGV NVKGYTAWSL LDKFEWDEGF SERFGLYYVD
FRNKNKPRYP KASVQFYKRI ISFNGFPNQR EVENWRRKAV ETCSSSNQLL AAARRKSQEH
AEMPKVWPVH DEV
//
