ID A0A3P9D977_9CICH Unreviewed; 1606 AA.
AC A0A3P9D977;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cytoskeleton associated protein 5 {ECO:0000313|Ensembl:ENSMZEP00005030662.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005030662.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005030662.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005030662.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 106582.ENSMZEP00005030662; -.
DR Ensembl; ENSMZET00005031627.1; ENSMZEP00005030662.1; ENSMZEG00005022836.1.
DR GeneTree; ENSGT00390000014757; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 269..503
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 440..478
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 521..753
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 787..1013
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 950..987
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1108..1346
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 493..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1050
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1606 AA; 178662 MW; 466D648B861D3100 CRC64;
MGDESEWMKL PIDQKCEHKI WKARLNGYEE ALKLFQKIED EKSPEWGKYL GLIKKFVTDS
NAVAQLKGLE AALAFIENAH FAGKTTGEVV SGVVTKVFNQ PKARAKELGM DICFMYIEIE
KAEVVQDELL KGLDNKNPKI VVACIETLRK ALSEFGSKIV TLKPVVKILP KQFESREKAV
RDEAKLLAVE IYKWIRDALR PSLQNINSVQ LKELEEEWVK LPSSPPKQTR FLRSQQDLKA
KFQEQQAQGG EQSDGDDGEE LVVAVDPYEL LEPVEILSKM PKDFYEKIEA KKWQERKEAL
EAVEALTKNP KLENGDYGDL VRALKKVVGK DANVMLVSMA AKCLAGLATG LRKKFGTYAG
QVVPTILEKF KEKKPQVVQS LQEAIDAIFL TTTFQNLSEE ILAVMDNKNP SIKQQASLFL
ARSFRHCTQA TLPKSILKPF CAALIKQVND SAPEVRDAAF EALGTAMKVV GEKAVNPFLA
DLDKLKLDKV SAVPPKKGKP TSAAGAKSKK SSDSKEFTES ELSAEVCQDL AAGVLPASCL
EQLDSANWKD RLASMEEFQR AVETMDKAAM PCQALVRMLA KKPGWKETNF QVMQLKLRIV
ALIAQRGQFS KTSASVVLDG LVDKVGDVKC GGNAKEGLTA IGEACSLPWT AEQVVSMAFS
QKNPKNQAET LNWLSNAMKE FGFAGINVKG FINNVKTALG ATNPAVRTAA ITLLGVMYLY
MGAPLRMFFE DEKPALLAQI DAEFEKMQGQ SPPPPIRFTK KVAAEEEGAE VEEQDEDAGG
GGQNIMDLLP RTDVSDKITT DLVSKIGDKN WKIRKEGLDE VAAIISEAKF IMANIGELPL
ALKGRLSDSN KILVQQTLSI LQQLATALGP GLKQHVKALG IPIITVLGDS KPNVRATAMT
TLQAWVEQTG MKDWLEGEDL SEELKRENPF LRQELLVFLI RLMFWDLMLC IPQLYACLED
RNGDVRKKAQ DALPTFMMHL GYDKMTKATG KLKPASKDQV VSMLEKARAV MPAKPAAPAK
TGGGKGSAES QLPSEDVADS KPEVKKVRGG MAAKKGAAGK KPVSKGLKDD EDKSGPLFIL
IANAKEQRIK EEKQLKILKW NFITPRDEYV EQLKTQMSTC FAKWLQDELF HFDFQRHVKA
IGVMIERLES ESEATISCLD LILKWFTLRF FDTNTTVLMK VLEYLKLLFA MLNRENYHLT
EYEANSFVPY LILKVGESKD VVRKDVRAIL AMLCKVYPAS KVFPFLMDGT KSKNSKQRAE
CLEELGCLIE GYGMNVCQPT PAKSLKEIAV HIGDRDTSVR NAALNTVVAV YNVCGDQVYK
LIGNLSEKDM SMLEERIKRS AKKAPTAVAK QTATDRSQKE HPTNSNATFL RKPAQEDPNN
KLNGRPSLHP SIPKEFQLDL DMIEMDQGRV CELPDLVQHK LDELLEPIMI PEPKMRSVSP
HFDELHNSTA STINFVISQV ASGDINTSIQ ALAQIDEVLR QEDKAEVMSG HIDQFLIATI
MQLRLINSTH MADDRVDKKD IIKLYSCIIG NMLSLFSMES LAREASMGVL KDLMHGLITL
MLDSRVEDVE DGTQVIRSVN LLVIRVLEKS DQTNMIRSVR RNSSLR
//
