ID A0A3P9DAF5_9CICH Unreviewed; 587 AA.
AC A0A3P9DAF5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028};
GN Name=PES1 {ECO:0000256|HAMAP-Rule:MF_03028};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005031538.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005031538.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and
CC WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
CC {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000256|HAMAP-
CC Rule:MF_03028}.
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DR AlphaFoldDB; A0A3P9DAF5; -.
DR STRING; 106582.ENSMZEP00005031538; -.
DR Ensembl; ENSMZET00005032565.1; ENSMZEP00005031538.1; ENSMZEG00005023518.1.
DR GeneTree; ENSGT00940000174960; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03028};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03028};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03028}.
FT DOMAIN 323..416
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 447..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..490
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 68709 MW; 0BACAF416DC24E01 CRC64;
MGGLQKKKFE RGSATNYITR NRARKKLQLS LPDFRRLCIL KGIYPHEPKH KKKVNKGSTA
PRTFYLLKDI RFLLHEPIVG KFREYKIFVR KLKKAYGKTE WSAVERLREN KPTYKLDHII
KERYPTFIDA LRDIDDALCM CFLFSTFART GKCHVQTIQL CRRLTVEWMN YVIASRSLRK
VFLSIKGIYY QAEVMGQLIT WVVPYQFSHD HPVDVDYRVM ATFTELYTTL LGFVSFRLYS
SLNLVYPPKL DSNGESEPKE ESEDDYAMNS ESYLEKLSAL SASLARVVSS ADEEEAQLDQ
FPSEGEDMEK MEAREKELKQ QEAQKKLFEG LKFYLNREVP RESLAFVIRC FGGQVSWDKS
VCIGSTYDVT DETITHQIID RPSVGKQYIN RYYIQPQWLY DCVNAKILLP VEDYFLGGTL
PPHLSPFVEE KEGDYVPPEK LKMMALQRGE KPGNEQEEDE EEEEEEGEQE EEEEQEEDDN
GDEEDDEEEV AEEKNLKKME EQRSQGKSLH VKVTPGKLKV ENKARLEQEE KAEEKRLAIM
MMKKKEKYLY DKIMFGKKRK VREANKLAAK RKAHDDSEKA KKKKHPE
//
