ID A0A3P9DC66_9CICH Unreviewed; 474 AA.
AC A0A3P9DC66;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=NADPH oxidase 4 {ECO:0000313|Ensembl:ENSMZEP00005031736.1};
GN Name=NOX4 {ECO:0000313|Ensembl:ENSMZEP00005031736.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005031736.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005031736.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P9DC66; -.
DR STRING; 106582.ENSMZEP00005031736; -.
DR Ensembl; ENSMZET00005032769.1; ENSMZEP00005031736.1; ENSMZEG00005023671.1.
DR GeneTree; ENSGT00940000159621; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF209; NADPH OXIDASE 4; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..343
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 474 AA; 55188 MW; 41C6DDA5BF46A90C CRC64;
YFTGQQYHYL YKMLGLGLCI SRASATVLNL NCSLVLLPMC RSLVTFVRGT RMTRRLLDKS
KTFHVACGVA ICIFSVMHVS AHLVNVVRFS VRYSDDFPAL NLARYRGELL SLVPGVTGVL
LVLILFLMFI SSSYCVRMSN YEIFWYTHNL FIVFYVILMI HMVGGALKYQ TNIEAHPLVA
SEPTRAAPSS REMNWTRVKK RRGDATRTLA SSHIIPRSEC TWLWVSGPLC LYCVERFYRY
IQSRDPVTIV TVIRHPCDVV ELRMLKKNFK ARPGQHILLN CPGVSSFENH PFTLTMCPTE
NKETLGIHLR VVGDWTERFT QLLLPEPRID MEILPMAQKR RYPNDGWMGF RLQRLYFVWV
CKELQSFYWF AELLCALHHK LWNENRPDYF NLKLYISQPD SLQVIEKYRP LTSRMQIGRP
RWKLLFDEIG KSNKHKRVGV FCCGPKGISR TLHRLCNSPQ YNGTTFEFNK ESFS
//
