ID   A0A3P9DEJ4_9CICH        Unreviewed;       551 AA.
AC   A0A3P9DEJ4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005032587.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005032587.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC       {ECO:0000256|ARBA:ARBA00010107}.
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DR   AlphaFoldDB; A0A3P9DEJ4; -.
DR   Ensembl; ENSMZET00005033645.1; ENSMZEP00005032587.1; ENSMZEG00005024277.1.
DR   GeneTree; ENSGT00940000157744; -.
DR   Proteomes; UP000265160; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 4.10.320.30; -; 1.
DR   Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002717; HAT_MYST-type.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR040706; Zf-MYST.
DR   InterPro; IPR002515; Znf_C2H2C.
DR   InterPro; IPR036060; Znf_C2H2C_sf.
DR   PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR10615:SF210; HISTONE ACETYLTRANSFERASE KAT7; 1.
DR   Pfam; PF01853; MOZ_SAS; 1.
DR   Pfam; PF01530; zf-C2HC; 1.
DR   Pfam; PF17772; zf-MYST; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF103637; CCHHC domain; 1.
DR   PROSITE; PS51726; MYST_HAT; 1.
DR   PROSITE; PS51802; ZF_CCHHC; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01143}.
FT   DOMAIN          273..547
FT                   /note="MYST-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51726"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        449
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ   SEQUENCE   551 AA;  63841 MW;  FD4CD393503E172F CRC64;
     MPRRKRTAGS SSDGTEDSDF SADVEHAEAA EIVHRRSSTR LTRASLRLSR SSQDIKQGAD
     RDETPPRTPT GNAPSSESDI EVSSPSNDLE DERLAKELSL KEAAAHDLSH RPKRRRFHES
     YNFNMKCPTP GCNSLGHLTG RHERHFSISG CPLYHNLSAD ECKVHASTRD KQAEERTLSH
     RQDENRHSTR NQAPTERQLR YKEKVTELRR KRNTGLNKEQ KEKYMEHRQS HGTSREPLLE
     NITSDYDLEL FRKAQARASD DLEKLRLAGQ VSEGSNMIKT IVFGRYELDT WYHSPYPEEY
     ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY RKGNISVFEV DGKKNKIYCQ
     NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA DNTGCHLVGY FSKEKNSFLN YNVSCILTMP
     QYMRQGYGKM LIDFSYLLSK VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLNNFQGKEI
     SIKEISQETA VNPVDIVSTL QSLQMLKYWK GKHLVLKRQD LIDDWKAKET KRGNSKTIDP
     TALKWTPPKG T
//