ID A0A3P9DI38_9CICH Unreviewed; 779 AA.
AC A0A3P9DI38;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Matrilin 2 {ECO:0000313|Ensembl:ENSMZEP00005034054.1};
GN Name=MATN2 {ECO:0000313|Ensembl:ENSMZEP00005034054.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005034054.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005034054.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005034054.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9DI38; -.
DR Ensembl; ENSMZET00005035252.1; ENSMZEP00005034054.1; ENSMZEG00005025451.1.
DR GeneTree; ENSGT00940000158008; -.
DR Proteomes; UP000265160; LG11.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF35; MATRILIN-2; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF10393; Matrilin_ccoil; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..779
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017943573"
FT DOMAIN 57..236
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 535..707
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 779 AA; 86809 MW; 11DFD583CE0D8C66 CRC64;
MLSSFITMRC LALGLFCLLC CNAAQTYRRR PRPITARSNT TFPIKAVENP CKAIPLDFIF
VIDSSRSIRP NDYEKVKTFI INLLQFLKIG HNATRVGLLQ YGSVVQPEFS LSTYTTKSEV
EQAVRNMEHL ATGTMTGLAI QYTMETAFTE EHGARPMNLH IPRIAMIVTD GRPQDTVEEI
AAQARQAGIQ IFAIGVGRVD MNTLRAIGSE PHSEHVHLVA NFSQIETLIS VFQSKLCGGS
DMCEVVDHQC QHICVSSPAS YRCKCREGYI LNPDGKTCTA EDTCAVVDHG CEHICANLPR
GYECLCRPGY QLTIDLKTCN RIDHCDLGNH GCEHNCVTVP ESYICTCKRG YVLNLDGKTC
SKIDHCADGA HGCEQEFMST EDSCVCKCRK GYTLESDGKT CKKIDHCADV AHGCEQEFMS
TEDSCVCKCR KGYTLEPDGK TCKKIDHCAD GTHGCEQEFM STEDSCVCKC RKGYTLRPDG
KTCQSLDLCQ TVHHGCEHQC VSTNDSYICR CFEGFMLAED GKSCKKPECS EGVMDLVFVI
DGSKSLGPNN FELVKQFVNS IVDSLDISKM GTHVGLLQYS TKVRTEFTLG QYSTAQHIKS
AVNRMQYMGR GSMTGSALRH MFESSFSTKE GGRFNIPRVS IVFTDGRSQD DVSEWATKAK
NSGITIYALG VGKAIEQELR EIASEPDEKH LYYAEDFEKM AEITKKLKSR ICADKPSDEN
MCQCENMIMF QNQVTEKLKS LVQNNILLCS LHRYQCSGLP LTNYFMCHSC VLLCVFLKP
//
