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Database: UniProt
Entry: A0A3P9DKP3_9CICH
LinkDB: A0A3P9DKP3_9CICH
Original site: A0A3P9DKP3_9CICH 
ID   A0A3P9DKP3_9CICH        Unreviewed;       483 AA.
AC   A0A3P9DKP3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Caspase-8 {ECO:0000313|Ensembl:ENSMZEP00005034964.1};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005034964.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005034964.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   AlphaFoldDB; A0A3P9DKP3; -.
DR   STRING; 106582.ENSMZEP00005034964; -.
DR   Ensembl; ENSMZET00005036209.1; ENSMZEP00005034964.1; ENSMZEG00005026157.1.
DR   GeneTree; ENSGT00940000166591; -.
DR   OrthoDB; 2873736at2759; -.
DR   Proteomes; UP000265160; Unplaced.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00032; CASc; 1.
DR   CDD; cd08792; DED_Caspase_8_10_r1; 1.
DR   CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR   PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01335; DED; 2.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PIRSF; PIRSF038001; Caspase_ICE; 2.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SMART; SM00031; DED; 2.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
DR   PROSITE; PS50168; DED; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          2..78
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          94..171
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          240..364
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          397..480
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   483 AA;  55147 MW;  5E03D6C44D438DB4 CRC64;
     MMDRLTLSHI DEGLDSSEVA ELCFLCRDVV TRRRLENIKD AKDLFLRLEE KGLLQNDAFL
     RQLLYTIHRA DLLRVLETDS RPPEETDASP VLSDYRKTLY SIYNGFTTEN FEKLKFLLTD
     QLGRRQMELS KTPLDVFAEM EKSALLSETD VSLLHKALQE CDQQLAITLE EYTQGGRQQR
     QQFTLPPDVS MDIERTHEPL SITETQPNYR RESINTDAQL ETNPTSLPDQ SDYYTLTHNP
     RGWCVVFNNE IFTATHLSNR KGTQKDADTL KEVFTRLGFQ VKIHNNCTAE QMEKKINDLG
     RINFTNHDAL VVCVLSHGEK GCVFGTDGGK VLLKELTDPF TSGRASTLAG KPKLFFIQAC
     QGEEYQKGYY PSSREDEKQN KGALQSDASI PDEAVLVPEL ADFLIGMATV EEFKSFRNTV
     TGSIYIQELC KQLTIAARRQ EMDDILTVLT RVNREVSKGE YLSHKQMPQP NYTLTKKLVL
     KFV
//
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