ID A0A3P9DKP3_9CICH Unreviewed; 483 AA.
AC A0A3P9DKP3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Caspase-8 {ECO:0000313|Ensembl:ENSMZEP00005034964.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005034964.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005034964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; A0A3P9DKP3; -.
DR STRING; 106582.ENSMZEP00005034964; -.
DR Ensembl; ENSMZET00005036209.1; ENSMZEP00005034964.1; ENSMZEG00005026157.1.
DR GeneTree; ENSGT00940000166591; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08792; DED_Caspase_8_10_r1; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 2.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 94..171
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 240..364
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 397..480
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 483 AA; 55147 MW; 5E03D6C44D438DB4 CRC64;
MMDRLTLSHI DEGLDSSEVA ELCFLCRDVV TRRRLENIKD AKDLFLRLEE KGLLQNDAFL
RQLLYTIHRA DLLRVLETDS RPPEETDASP VLSDYRKTLY SIYNGFTTEN FEKLKFLLTD
QLGRRQMELS KTPLDVFAEM EKSALLSETD VSLLHKALQE CDQQLAITLE EYTQGGRQQR
QQFTLPPDVS MDIERTHEPL SITETQPNYR RESINTDAQL ETNPTSLPDQ SDYYTLTHNP
RGWCVVFNNE IFTATHLSNR KGTQKDADTL KEVFTRLGFQ VKIHNNCTAE QMEKKINDLG
RINFTNHDAL VVCVLSHGEK GCVFGTDGGK VLLKELTDPF TSGRASTLAG KPKLFFIQAC
QGEEYQKGYY PSSREDEKQN KGALQSDASI PDEAVLVPEL ADFLIGMATV EEFKSFRNTV
TGSIYIQELC KQLTIAARRQ EMDDILTVLT RVNREVSKGE YLSHKQMPQP NYTLTKKLVL
KFV
//