ID A0A3P9DM93_9CICH Unreviewed; 696 AA.
AC A0A3P9DM93;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Exostosin-1b {ECO:0000313|Ensembl:ENSMZEP00005035307.1};
GN Name=EXT1 {ECO:0000313|Ensembl:ENSMZEP00005035307.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005035307.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005035307.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005035307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR AlphaFoldDB; A0A3P9DM93; -.
DR Ensembl; ENSMZET00005036555.1; ENSMZEP00005035307.1; ENSMZEG00005026388.1.
DR GeneTree; ENSGT00940000155321; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000265160; LG22.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 105..390
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 453..679
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 80744 MW; AE1009951A6085E5 CRC64;
MQAKKRYLIL LSAGACLVLL FYLGGVQLPA ASRSRHDRSR NGHRPEQPWP HFSDPLHLFL
PWDQTDTEDY NLHISPRQKR DINTSVYKGK RCRMDSCFDF SLCRKNGFKV YVYPQQKGEK
ISESYQNILS TIEGSRFYTS DPGQACLFVL SLDTLDRDQL SPQYVHNLKT KVQNLPLWND
GRNHLIFNLY SGTWPDYTED LGFDIGQAML AKASISTENF RPNFDVSIPL FSKEHPRTGG
ERGYLKYNSI PPFRKYMLVF KGKRYLTGIG SDTRNALYHV HNAEDVVLLT TCKHGKDWQK
HKDARCDKDN AEYDKYDYKE MLHNSTFCLV PRGRRLGSFR FLEALQAACV PVMLSNGWEL
PFSEIIDWNT AAVIGDERLL LQIPTTVRSI HQDKILSLRQ QTQFLWEAYF SSVEKIVLTT
LEIIQDRVLE HASRSSLMWN SHPGGLFIQR TNKTSFVCSL FQIIVLWNCD KPLPAKHRWP
ATSVPVIVIE GENKVMSSRF LPYEIIVTDA VLSLDEDTVL STTEVDFAFT VWQSFPERIV
GYPARSHFWD SNKERWGYTS KWTNDYSMVL TGAAIYHRYY HFLYTNYLPT SLKSMVDQLA
NCEDILMNFL VSAVTKLPPI KVTQKKQYKE TMMGQSSRAS RWADPDHFAQ RQTCMNKFAS
WFGAMPLVHS QMRLDPVLFK DQVSILRKKY RDIERL
//