ID A0A3P9DMQ3_9CICH Unreviewed; 533 AA.
AC A0A3P9DMQ3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Frizzled-4 {ECO:0000256|ARBA:ARBA00018149};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005035578.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005035578.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR RefSeq; XP_004543937.1; XM_004543880.1.
DR AlphaFoldDB; A0A3P9DMQ3; -.
DR STRING; 106582.ENSMZEP00005035578; -.
DR Ensembl; ENSMZET00005036835.1; ENSMZEP00005035578.1; ENSMZEG00005026584.1.
DR GeneID; 101475019; -.
DR KEGG; mze:101475019; -.
DR CTD; 8322; -.
DR GeneTree; ENSGT00940000157141; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0001895; P:retina homeostasis; IEA:Ensembl.
DR GO; GO:0061298; P:retina vasculature development in camera-type eye; IEA:Ensembl.
DR CDD; cd07448; CRD_FZ4; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041765; FZ4_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..533
FT /note="Frizzled-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018005553"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..154
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 212..496
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 511..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 46..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 83..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 110..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 114..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 533 AA; 59152 MW; 80C89DB28F4873F8 CRC64;
MPGMMVSLTG SAVLLLSGLV APLCLVRAFG DEVEEMTCDP IRISMCQGLG YNVTKMPNLV
GNVLQSDAEL QLTTFTPLIQ YGCSSQLKFF LCSVYVPMCT DKVPIPIGPC GSMCLSVKKK
CLPVLHEFGF IWPEELNCSL FPPQNDHNHM CMEGPGDEDP PYQPVRHPPH QEECHALGSA
PDQYTWLKQT ESCTLQCGYD SGLYRRGAKV FTDAWMAVWA VLCFLSTTLT VLTFLLDSQR
FSYPERPIIF LSMCCNLYSV AYLVRLTLGR ERVSCDLDAA AVPILVQEGL KSTGCSIVFL
LLYFFGMASS LWWVILTLTW FLAAGLKWGH EAIEMHSSYF HIAAWAIPAV KTIVILIMRL
VDADDLTGLC YVGNQQQEAL TGFVVAPLAT YLLIGTLFIC AGLVALFKIR SNLQKDGAKT
DKLERLMVKI GVFSVLYTVP ASTVIGCYLY QLSNWGEFRA STQDSYVASE MLRIFMSLLV
GITSGMWIWS AKTLHTWQRC SARLLRDSRA SRGGKRAPGE SWIKPGKGNE TVV
//
