ID A0A3P9DMT7_9CICH Unreviewed; 703 AA.
AC A0A3P9DMT7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Zinc transporter ZIP4 {ECO:0000256|ARBA:ARBA00039394};
DE AltName: Full=Solute carrier family 39 member 4 {ECO:0000256|ARBA:ARBA00042777};
DE AltName: Full=Zrt- and Irt-like protein 4 {ECO:0000256|ARBA:ARBA00041703};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005035749.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005035749.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005035749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR AlphaFoldDB; A0A3P9DMT7; -.
DR STRING; 106582.ENSMZEP00005035749; -.
DR Ensembl; ENSMZET00005037012.1; ENSMZEP00005035749.1; ENSMZEG00005026701.1.
DR GeneTree; ENSGT00940000160042; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000265160; LG22.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF21; ZINC TRANSPORTER ZIP4; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..703
FT /note="Zinc transporter ZIP4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018285991"
FT TRANSMEM 371..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..224
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 234..352
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 264..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 77313 MW; C5E483F8E09A93C7 CRC64;
MISSSPFLLL LLSGWGLLSF VSGSPAVEEA YEAVVSIVSP GQQYLTGESL HSLFNTLEHR
VHCGEVPCEK CDLADAVHQL IGNPDVQYEE ETRRNSVNVA VTVSQFTALA SGSVLYLSSP
GLVCTAIKTG TWGEETEKFL HKFTHNDPHE HKSEANHDHE HIDVHGLEGV IQELRSHYDP
TESENCISAS GIMAQVDASS GDQKQEVGAV LGYVLYHALQ GHCFADQSLP DESFFVNYIM
EQLGSENFTI LDLKALMKSL NIGPSSEEDH GHEHTADEHA DHDDNVQRWR KRSSDSVEGR
ESNNTWEQRC FSAEELVQIY GLAENSSASS GLGRPGVVQL SPALVQQILS GACADITDPE
KPDGLSKAER YLYATIANFL ITVISMFGIV VLLCAACTSV FQMCIQFCIS LAVGSLTGDA
LLHLMPTFLG LHVHSDNGGS SEHSSHSHEE ETPDYVYKML VLIAGIYCFY LMEVSFSLIT
YGDKHNDHKH HHGEESEPHH CDHGRVLEMY QQEQKQKDTK SQSISKEDLV SCEDNEKPLP
EPKERTREQR LLPYMITIGD TIHNFADGLA LGAAFALSWK SGLATSLAVL CHELPHELGD
FAILLNCGLS VRKALALNIA STLTSFIGMY VALSVATDLA TQQWIGAITA GLFLYVGLAD
MLPTMIHISN KKPWMTFLLQ NVGLLAGWGI LLLLSLYEEK ISF
//
