ID A0A3P9DN15_9CICH Unreviewed; 1486 AA.
AC A0A3P9DN15;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=A kinase (PRKA) anchor protein 9 {ECO:0000313|Ensembl:ENSMZEP00005035678.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005035678.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005035678.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005035678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR STRING; 106582.ENSMZEP00005035678; -.
DR Ensembl; ENSMZET00005036940.1; ENSMZEP00005035678.1; ENSMZEG00005026646.1.
DR GeneTree; ENSGT00730000110871; -.
DR Proteomes; UP000265160; LG22.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.20.1480.30; Designed four-helix bundle protein; 1.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF1; A-KINASE ANCHOR PROTEIN 9; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 1284..1365
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 75..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 377..467
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 495..558
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 995..1036
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1184..1211
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 81..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1486 AA; 169232 MW; 62895C76E9A30344 CRC64;
MEEKDNEIAL LNEQITKLQH METTSDNKVM QNRDELIKDL ESQVECLRSE QERLKRKNEE
ELDQLNEVIE KLQQELANIE QKQPTEEEED TKAESEGDAC GPSKDEYDKM KQRMDLATKE
LEALKKEHSK LLETYLRLKE SAEALAETEN LESSEGELEE ALREKTAGLV VLQAQVQALE
ESASSRVEEL GVRIEELEGL VSEKDSEISH CRFLLEQSQS HAEDLQKKML NLEEHLREKV
AAALVSQATL EAFQQQSVET RQEQDPQKPP EPHVEPQSYE SGDFGIPQMD VSRLCQQTQV
PTGKVVRLTQ KLRELEVGLS GMQKDQELQK QLLSSSEEEV LEYERRLTVL VDLLSQMKAG
TLQRTSLPAR SSYMERNEKL QEELQVSEGS VSKLKEELQE VRKDMDTTKE ELNSYMEHNE
KLQEELQVSE GSVSKLKEEL QEVRKSMDTT KEELNSYKRH NENLHKELHT REISISKLQG
ELQEVQTVLM KTAESEEMEE VIGEYEEKIV QMQELHAAEI LDMEARHISE SENLRRDTQA
LEDECKALKA VIEKLRSAEV RKRDVLDVYS SSDYSQRTGY DLPSLQQEFR TTPEGARRDE
PLPDRIKTLL REVHQEGMQV LSLSELPLSE SEPGDRFNVQ GWVKERDALL DTIESLKNFI
SQMQTHRESQ MSGSVDWRGE LLDAVRQVFI KERNVLKNAL YSQLDLLDTS DAIIHLNQLE
RRLAEVHFAE NKSFCILYLL NVCLCPSGAR SAVSLAGEGS IKEQRERVGA DGAGGADRLL
VEELKGELSQ TKLELETTLK AQHKHLKELD TLRAEVSQKA AEVDALNDEL TEERKKSRDL
QWAMEKEKCQ TGRTEESRRE ELEDLQLSLE EQKNHVAQLK LTVEQERQAS SQLSHQAEEE
RLSLHRRLQE LQVQLETERA KAQEMSTALG RERDLRTGVS SDGGHLHEEQ VQKDGRSSEE
GGGLLERLQR ELDDKHAQVR CYSCFNCLMT PDFKLERLEA EMAKVQEQLR RELENRQSLE
EENERLEGRL NQLGEQREGM GPVEADGRSV SGTDFTLKRL LVTFIVSDHQ AVWHSDSTDR
TKDWVLQQKS GNLHTESSSA SPHKEVSSTG HSSGRNTHSL LVSSQNQLFA SAFTKQHLLS
FTRGCDCLSC FPQSASLLAG GSSSSSNTLT ERLLRQNAEL TGFVSRLTEE KNDLRNHTLR
LEEELRRYRQ VGLGRRGASK MDSAGLLLSQ EREAWAREKI RLEKALHLAQ SQVARLRGEI
RSENLREITG PDADNAALKR MYGKYLRSES FRKALIYQKK YLLLLLGGFQ ECEEATLSLL
TRMGGRPSLS SLESLSQRCR GAMRFRSIAR VSIALSRMRF LVKRWHRATG MSSTASCAVS
TEARDSPYLH PGGPEMYRDR GSGGGGMSSS RGRSGRESPR LAVSSTHHRF HMSGDHGPLT
CSHLQNYDPD RALTDYISRL EALQRRLGSV TSGASSYAQL HFGLRR
//
