ID A0A3P9DR79_9CICH Unreviewed; 1237 AA.
AC A0A3P9DR79;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=VPS10 domain-containing receptor SorCS3 {ECO:0000313|Ensembl:ENSMZEP00005036954.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005036954.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005036954.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005036954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9DR79; -.
DR Ensembl; ENSMZET00005038244.1; ENSMZEP00005036954.1; ENSMZEG00005027529.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000265160; LG13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF45; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 ISOFORM X1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1237
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017995090"
FT TRANSMEM 1132..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 867..934
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 827..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 139069 MW; 08934AC21C68DF55 CRC64;
MALWSFWGFS LLALVLLCPF HPKFVARAEI SFSTKLDRFY RLDVTPLDAR VARKSAEIKV
SLKIDNNTKV FSAYETNTAG ALKRNHGQQV WNETQSGNEA PIDIKTNYSS GLNIPDKKYD
NIFEDKEGRF KANIMLENTF SAGRKKAKRS VGATYNENVD RSISGEAYSR ERFVQTVQGV
SSARPEYREA RVSNPRQNEP HLDTSTFALS GDSAHNQAMV HWSGHNSSVI LILTKLYDFN
LGGVTESSLW RSTDYGSTYT KLNDKVGSRT VLSYLYVCPT NKQKIMVLSD PEVESAVLIS
SDEGASFEKH PINFNILSLL FHPAQENWIL AYSHDSKLYS SMDFGRKWQL VHDNVMPGRF
YWAVMGLDRE SDVVHIETRI GKGREYCTPC RAQRCTEGNR QYLFPGHVDT NSLVVQDEYV
FTQVTKSGRA SYFVSYMRES FKRMKLPKYC LPKDMHIIST DEKQVFAAVQ EWNQNNTYSL
YISDSPGVYF ILSLENLRTS RGLAGNLLVD FYKVEGINGM YLANKLVDNY IKTFITYNKG
QTWSLLPAPA TDVAGNNLHC ILPFCSLHLQ LEMSENPYTS GPITSKKSVP GIIVATGNIG
TQLSSANLGM FITSDAGNSW RQIFDEEYNV WFLDNGGALL AVLQAAAPIR HLCLDEGKKW
DRHSFSLAPL YVDGVLMEPE SDNHIITFFG HFSHRSEWQL IKIDYKGLFS RRCMDGDYQT
WYLHNKGELC VMGEKQIYMK RRPGNRCMLA QDYSRIYSSE PCPCTAYDFE CDYGWERQAD
GNCSPAFWFN PNGAAKSCST SQSFLNSTGY RKVLSNNCKE AGRNVYSPRR QPCHPRAPRG
LQLSTSQGEL SSPVGSNVTF MVSLNEGDSL RTSIQLDFGD GIKITYSNLS RADDGIKHIY
RTTGIYRVTA TAENSQGSDS STLFLHITSP LERVYLSAPI VAVRGKEANL TAVVWPSHTR
TLTFFWWFDN SSEPIITLEG SISHTFQSEG KSKVTVQVAS GSTVMQDSKV TTVKEFFRSL
LLSFSPALDE HNPDIPEWRE DIGRVVRTAL SQVSGIHEDQ LLVSLYPGLP TTAELFILPD
EQTSTDNILG IGHGLGKSNE FNTYYVKSLV LIYGVWLSAP LVDSNSLPSG SAMLMLLIVV
FVGLAAFFIY KFKRKIPWVH VQTEDSHEKD PEVISTVGQN DTMSKVKLSE FPSQKELMEK
ELEARNIGNP FKMPLLQANC DCVVEKCAVI ITNGVVT
//
