ID A0A3P9DTN8_9CICH Unreviewed; 540 AA.
AC A0A3P9DTN8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005038110.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005038110.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR RefSeq; XP_004543942.1; XM_004543885.2.
DR AlphaFoldDB; A0A3P9DTN8; -.
DR STRING; 106582.ENSMZEP00005038110; -.
DR Ensembl; ENSMZET00005039518.1; ENSMZEP00005038110.1; ENSMZEG00005028506.1.
DR GeneID; 101476383; -.
DR KEGG; mze:101476383; -.
DR GeneTree; ENSGT00940000155336; -.
DR OrthoDB; 70287at2759; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..540
FT /note="Tyrosinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018274474"
FT TRANSMEM 477..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..222
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 386..397
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT REGION 512..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 61176 MW; 8A2AE249D9DCBB73 CRC64;
MRRLCMSLVF LQLIGACVSQ FPRPCATSEG LRTKECCPLW DGDGSACGAL SGRGFCTDVV
ISDEPHGPQY PHSGIDDRER WPLAFFNRTC RCAGNYGGFN CGECRFGYWG SNCAEYRESV
RRNILTMSTA EQQKFISYLN LGKNTINRDY VIATGTRAQM GENGENPMFS DINTYDLFVW
MHYYVSRDAL LGGPGNVWQD IDFAHESAAF LPWHRVFLLH WENEIRKLTG DFNFTIPYWD
WRNSQTCDVC TDALMGGRNS LNPNLISTAS VFSSWKVICT QSEEYNSREA LCNATGEGPL
LRNPGNHDTN RVQRLPNSDD VEFAVGLPEY ETGPMDRFAN MSFRNVLEGF ASPQTGMAVS
GQSTLHNALH MFMNGSMSSV QGSANDPIFL LHHAFIDSIY ERWLRNHQPP RNSYPRTNAP
IGHNDGYYMV PFLPLYRNGD YFLSNKALGY EYAYLLDPGQ RFVQEFLNPY LQQAQQIWQW
LVGAGILGAL IAAIIAVIIV FARRKWKRNQ RKKRASSYGE RQPLLHSSSE EGSSSYQTTL
//