ID A0A3P9DUX2_9CICH Unreviewed; 716 AA.
AC A0A3P9DUX2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0000259|PROSITE:PS50188};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005038122.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005038122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the SNTX/VTX toxin family.
CC {ECO:0000256|ARBA:ARBA00006480}.
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DR AlphaFoldDB; A0A3P9DUX2; -.
DR Ensembl; ENSMZET00005039530.1; ENSMZEP00005038122.1; ENSMZEG00005028497.1.
DR GeneTree; ENSGT00390000014380; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR048997; Stonustoxin-like_helical.
DR InterPro; IPR040581; Thioredoxin_11.
DR PANTHER; PTHR31594; AIG1-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31594:SF16; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF21109; Stonustoxin_helical; 1.
DR Pfam; PF18078; Thioredoxin_11; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Hemolysis {ECO:0000256|ARBA:ARBA00022735};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 690..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 488..697
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 716 AA; 81653 MW; 8CC8213BA4DF07B9 CRC64;
MRPSSVLEVA ALGQPFSLGM LYDARRGKLI PGVTLWNSKT LQKKPVEHNQ HSSEFHINAT
DSIEKKSALL DVNGSLKASF LGGLIEVEGS AKYLNDRKKS HHQCRVTLQY KATTKFKQLI
LTPDETKNSQ EAKNVKRLAT HVVTGILYGA NAFFVFDSEK LDDSNIQAIE GSMQAVIKKI
PSFNVDGKVD IKLSDEEKAV TDKFTCKFYG DFILESNPAT FEDAVKTYIQ LPKLLGENRE
NCVPLKVILM PLKKFHPKAA YMISSGFISK AEDTLQELHN LDIRCNDLLE DRVARSFPQI
QEKLGRFKKL CQYFRSSLQE TIAEKLPSIR AGEENEQELV EVFDDRDKSP FSQEKLTKWI
KDEEREVTII RYFVDMMEGA KIISDQSELD REVFKPGVEE VLCFVFTSLK SIDPYLQNMS
DYLEKKKLEG TDGNTPPTQD QWYFSDDVIK QMTEKAKVVH DHAKALKTKN SFHFLVAAIS
NDNYKGGSIY HYRKNFLITE NFSGYACGLS LDPNTAHCEL LLSEGDKEVT RGEKQQYPDL
PERFSEVPQI LCREELTGRC YWEVECKAFL QACVDVDVCY KQLERKGNND ACRLGNNTIL
WCFTHHPDQG SGENPLSFCA KHNNESKYYP VHPTGCPRLG VFLDWVAGTL SFYCVLSDKL
SHIHSFRTKF SEPVYPAFFL HNQPEFSNTA GLMSAYFFIL PFMIIVRFPT SVKLMF
//
