ID   A0A3P9MS19_POERE        Unreviewed;       244 AA.
AC   A0A3P9MS19;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Transmembrane protein 192 {ECO:0000256|ARBA:ARBA00014635};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000000128.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000000128.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000000128.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC       Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family.
CC       {ECO:0000256|ARBA:ARBA00006314}.
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DR   AlphaFoldDB; A0A3P9MS19; -.
DR   STRING; 8081.ENSPREP00000000128; -.
DR   Ensembl; ENSPRET00000000152.1; ENSPREP00000000128.1; ENSPREG00000000120.1.
DR   GeneTree; ENSGT00390000013749; -.
DR   OMA; VQHHHSR; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000000120; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; TRANSMEMBRANE PROTEIN 192; 1.
DR   PANTHER; PTHR31592:SF1; TRANSMEMBRANE PROTEIN 192; 1.
DR   Pfam; PF14802; TMEM192; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          188..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..207
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  27263 MW;  8475F452E9C81C96 CRC64;
     LDQAGVLLQQ AGSSADMTRS TEEDSLVDGP LISADALQSA MRREFQSVPT TCPAGFLSLM
     HVRNALSAPV LLVSSGCVRD AVGVCGRVVV IVFGKVFLWV LMLLHTAWMH HHHSRVRSRG
     YLSFYRRTQR LKQLPLVIHS TGGTAHSSLE LRFHYIHGVI LVAVPCLLYY TVRVMQFNRR
     RAAPDVSQEE HSHSYSVTNQ PTETGFRGSS GLEEVVEKQA DLIEYLKQHN TLLSKRLLNH
     TAQH
//