ID A0A3P9MSY1_POERE Unreviewed; 1662 AA.
AC A0A3P9MSY1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Complement C3-like {ECO:0000313|Ensembl:ENSPREP00000000456.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000000456.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000000456.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000000456.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_008429577.1; XM_008431355.1.
DR STRING; 8081.ENSPREP00000000456; -.
DR Ensembl; ENSPRET00000000484.1; ENSPREP00000000456.1; ENSPREG00000000341.1.
DR GeneID; 103477706; -.
DR KEGG; pret:103477706; -.
DR GeneTree; ENSGT00940000154063; -.
DR OMA; GESYLIM; -.
DR OrthoDB; 4033541at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03583; NTR_complement_C3; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035815; NTR_complement_C3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1662
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018190942"
FT DOMAIN 690..725
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1511..1658
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1662 AA; 186701 MW; 007026193A914DB4 CRC64;
MGPGRRMHWL QLRLIACLAF FSLFSPAAGS PTHVMSAPNL LRIGTEERIF IEIQDNVNRN
RNVDVEIRVM NHPTKTTTFA STSVTLTDQT NFQAFAKIVI PPETFANDRN GKHYVTLQAQ
FPDQLLEKVA LVSFQSGFIF IQTDKPIYTP SSSVRYRIFA MWPDMQSQTD TSVNFEILTP
AGIVIETKII SLRNLASGIY TDEYRLGNIV SFGNWKMVAN FHSNAAESFT TEFEVKEYVL
PSFEVKLLLP PKTPFFYVDS NALSITIKAT YTFGREVDGT AYAVFGFING DEKKSFPSSL
QRVAIQNGNG MVTLQKEHIT EIRQNILDLV GRSIYVSVSV LTESGSEMVE AELKGIKIVQ
SPYTIHFKRT PKYFKPGLSF DVTVEVLNPD GSPAEGIPVS VNPGGVLSTT KSNGMARLPI
NFGGEIQSLR ITAKTNYPPN APNRQATATM VALPYKSSSN SLLHLSVHTA EVALGESMKL
DLYFTQPESQ EKHITYLILS RGQLVKHFRE KNNNLNQMSV MVDITKEMLP SFRIVAFYHT
SSNELVSDSV WVDVTDTCMG KLTVEMKTPA ASYEPRKNIN VVVTGDPGAT VGMVAVDDAV
YILNNKNRLT QKKIWDVVEQ YDTGCTAGGG KDGRNVFYDA GLLFQSSHDG SPSRTELKCP
TATRRKRETT ITEVRTSLIS GFEDHLQKDC CLDGMKEIPI SYTCERRTEY IMDGPECKQA
FLHCCNEMKK QRDERKVEIL HLARSETDDY KVSNNDIVSR SNFPESWFWK DISLRCPAND
PNCNTATAQK TEALPDTITT WQLTAVSMSK THGLCVAKPL KIIIWKPFFI DLRLPYSAVQ
GEQLEIRAIL HNYDDNPITV RIEFKEEASI CSAAYKKKWF RSEVQVGRQT TRAVPFIIIP
MKHGSFPIEV KAAVKGSFHS DGVRKMLLVV PQGVLMQEHT KRILDPARKG GRQEEIINSD
IPMAHLVPNT PKTTLISLTG IGQMNTLLDN VISGESMGNL IRAPSGCGEQ NMAGVTLPVI
AALYLDKTNQ WEDVGFEKRN EAIQYIKTGY QAQFEFRKND GSFAIYPHRP STTWLTAYVA
KVFAMATAHV HIDKSMVCGA IKFLILQTQR PDGMFMEVGE VSDKRMIGDV GGVDSDASMT
AFCLIAMKES SVMCSDYVPS LPTSMRKAQA YLEQRLQWLT NPYAVALTSY ALVNFKKLDR
GVLFKHAAPD RTHWPVQKGK DATLEATAYA LLALVKDQAF EEAKPIVRWL SQQQRYSGGY
GATQATIMVY QAVAEYASNV NEPPFDLNVD VSVKGRSLMN KINLNNQNHY TTRTSKFDGI
NKNVTVTATG TGEAMFNMAS LYYAIPTKKE SDCEMFDLTL ELIEVSSEEN KKVYKLKIEV
LYKNTEHSAS MSILDIGLPT GYKFNKNDLD ALSAGRDHII DKYEANKELS EKGSLIIYLN
KVSNTRPEEI AFRIEQSMTV GFLQPAAVSV YEYYDIASEK RCVKFYRPQR KSGELLRLCQ
SEACLCAEEN CSKQRKEEIS NDNRLAKACE STESSKIDFV YKVVVVDFFD NYTTDSYTVR
ILQTFKQGTT DESPQGKSRT FLTYQHCREA LDLRPGKTYL IMGTSSDIHI VGTSFRYIIG
ETTWVEYWPT PEECQTDIHR PVCMDLEMME DQMGDFGCIM KK
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