GenomeNet

Database: UniProt
Entry: A0A3P9MUF7_POERE
LinkDB: A0A3P9MUF7_POERE
Original site: A0A3P9MUF7_POERE 
ID   A0A3P9MUF7_POERE        Unreviewed;       491 AA.
AC   A0A3P9MUF7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE            EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000000963.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000000963.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000000963.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC         in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC         N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC         Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC         EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC         Evidence={ECO:0000256|ARBA:ARBA00024496};
CC   -!- SIMILARITY: Belongs to the DCP1 family.
CC       {ECO:0000256|ARBA:ARBA00008778}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_008413035.1; XM_008414813.1.
DR   AlphaFoldDB; A0A3P9MUF7; -.
DR   SMR; A0A3P9MUF7; -.
DR   STRING; 8081.ENSPREP00000000963; -.
DR   Ensembl; ENSPRET00000001002.1; ENSPREP00000000963.1; ENSPREG00000000750.1.
DR   GeneID; 103468015; -.
DR   KEGG; pret:103468015; -.
DR   CTD; 55802; -.
DR   GeneTree; ENSGT00940000158818; -.
DR   OMA; IWFYDPQ; -.
DR   OrthoDB; 385293at2759; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000000750; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd09804; Dcp1; 1.
DR   Gene3D; 6.10.140.2030; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010334; Dcp1.
DR   InterPro; IPR031953; mRNA_decap_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16290:SF4; MRNA-DECAPPING ENZYME 1A; 1.
DR   PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR   Pfam; PF06058; DCP1; 1.
DR   Pfam; PF16741; mRNA_decap_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          448..490
FT                   /note="mRNA-decapping enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16741"
FT   REGION          167..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  53471 MW;  AB2A2D48F36773A7 CRC64;
     METLTAGHMM SLAALQRQDP YINKLLDVTG QVALYNFNSK VNEWEKTEIE GTLFVYSRSA
     SPHHGFIIMN RLSTENLVEP INKDLEFQLQ DPFLLYRNGN LGIYSIWFYD KRDCHRIAQL
     MVKIVKQEAD HALRKTPERV DPGRTNGVAE SRPIDILELL SKAKEEYQRA QSGETDTSAE
     LNVKTSINRA PEPSQSTHPA EKSSHTMVKQ ITVEELFGSP LPKEHSAQNA ASSSSSGNLP
     NVYVQNQPYP AAAHQAPLLT QQFSTHNPGS RQQPHGPAHI PAPYTLNPSP VFKHMVPMPD
     PQPHCSVSPL LMAPAGSEHH NNLTAPAAPS AAFLGQDIVG SLKPAASSVN SGIHKPILAP
     SFLPSTLVPP LSFQEPKKDV FSQPPKLIAP MSAIPMSPGL AVPGSDASVL LSPSAFQQTT
     NKTTTVPVIP SAPPDPSSAS RRAAQTLQAP CSKTQLQETL IHLIKNDSDF LSAIHDAYLQ
     SVSKDFSSMK L
//
DBGET integrated database retrieval system