ID A0A3P9MUF7_POERE Unreviewed; 491 AA.
AC A0A3P9MUF7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000000963.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000000963.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000000963.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC Evidence={ECO:0000256|ARBA:ARBA00024496};
CC -!- SIMILARITY: Belongs to the DCP1 family.
CC {ECO:0000256|ARBA:ARBA00008778}.
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DR RefSeq; XP_008413035.1; XM_008414813.1.
DR AlphaFoldDB; A0A3P9MUF7; -.
DR SMR; A0A3P9MUF7; -.
DR STRING; 8081.ENSPREP00000000963; -.
DR Ensembl; ENSPRET00000001002.1; ENSPREP00000000963.1; ENSPREG00000000750.1.
DR GeneID; 103468015; -.
DR KEGG; pret:103468015; -.
DR CTD; 55802; -.
DR GeneTree; ENSGT00940000158818; -.
DR OMA; IWFYDPQ; -.
DR OrthoDB; 385293at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000000750; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09804; Dcp1; 1.
DR Gene3D; 6.10.140.2030; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010334; Dcp1.
DR InterPro; IPR031953; mRNA_decap_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16290:SF4; MRNA-DECAPPING ENZYME 1A; 1.
DR PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR Pfam; PF06058; DCP1; 1.
DR Pfam; PF16741; mRNA_decap_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 448..490
FT /note="mRNA-decapping enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16741"
FT REGION 167..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 53471 MW; AB2A2D48F36773A7 CRC64;
METLTAGHMM SLAALQRQDP YINKLLDVTG QVALYNFNSK VNEWEKTEIE GTLFVYSRSA
SPHHGFIIMN RLSTENLVEP INKDLEFQLQ DPFLLYRNGN LGIYSIWFYD KRDCHRIAQL
MVKIVKQEAD HALRKTPERV DPGRTNGVAE SRPIDILELL SKAKEEYQRA QSGETDTSAE
LNVKTSINRA PEPSQSTHPA EKSSHTMVKQ ITVEELFGSP LPKEHSAQNA ASSSSSGNLP
NVYVQNQPYP AAAHQAPLLT QQFSTHNPGS RQQPHGPAHI PAPYTLNPSP VFKHMVPMPD
PQPHCSVSPL LMAPAGSEHH NNLTAPAAPS AAFLGQDIVG SLKPAASSVN SGIHKPILAP
SFLPSTLVPP LSFQEPKKDV FSQPPKLIAP MSAIPMSPGL AVPGSDASVL LSPSAFQQTT
NKTTTVPVIP SAPPDPSSAS RRAAQTLQAP CSKTQLQETL IHLIKNDSDF LSAIHDAYLQ
SVSKDFSSMK L
//