ID A0A3P9MYN9_POERE Unreviewed; 830 AA.
AC A0A3P9MYN9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Tuftelin-interacting protein 11 {ECO:0000256|ARBA:ARBA00015137, ECO:0000256|PIRNR:PIRNR017706};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000002431.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000002431.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000002431.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC disassembly during late-stage splicing events.
CC {ECO:0000256|PIRNR:PIRNR017706}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR017706}.
CC -!- SIMILARITY: Belongs to the TFP11/STIP family.
CC {ECO:0000256|ARBA:ARBA00010900, ECO:0000256|PIRNR:PIRNR017706}.
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DR RefSeq; XP_008417006.1; XM_008418784.2.
DR AlphaFoldDB; A0A3P9MYN9; -.
DR STRING; 8081.ENSPREP00000002431; -.
DR Ensembl; ENSPRET00000002479.1; ENSPREP00000002431.1; ENSPREG00000001742.1.
DR GeneID; 103470375; -.
DR KEGG; pret:103470375; -.
DR CTD; 24144; -.
DR GeneTree; ENSGT00390000012739; -.
DR OMA; QNEFNPH; -.
DR OrthoDB; 3060898at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000001742; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000390; P:spliceosomal complex disassembly; IEA:InterPro.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR022783; GCFC_dom.
DR InterPro; IPR022159; STIP/TFIP11_N.
DR InterPro; IPR024933; TFP11.
DR InterPro; IPR045211; TFP11/STIP/Ntr1.
DR PANTHER; PTHR23329:SF1; TUFTELIN-INTERACTING PROTEIN 11; 1.
DR PANTHER; PTHR23329; TUFTELIN-INTERACTING PROTEIN 11-RELATED; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF07842; GCFC; 1.
DR Pfam; PF12457; TIP_N; 1.
DR PIRSF; PIRSF017706; TFIP11; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR017706};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR017706};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017706};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|PIRNR:PIRNR017706}.
FT DOMAIN 152..198
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 94424 MW; 36DA186EC2B1271A CRC64;
MSMSHLYGRR EEEEEGVEIE SFEVTDWDLA NEFNPERRRF RQTKEQATYG IWADRDSDED
ERPSFGGKRS KDYTTPVSFV SAGVRKTAGE EKQQQQEGGS DDSDDDSPPA QPPPRATAPK
KLQMGTFGGN QSQRFAGGIQ SGKGIGSWEK HTKGIGQKLL QKMGYQPGKG LGKNAQGIVN
PIEAKVRKGK GAVGAYGNER THQSLQDFPV VDSEEEEEKE FKKELGQWRK DPTGTAGKKK
PKYSYKTADE LKAKGKMAYR GTPASAGELA QVKVIDMTGR EQKVYYSYSQ ISNKHSVPDE
APPSLATRDQ KGSGFALPEL EHNLQLLIDL TEQDILQSAR RLQHEKDVVV SLSHESRALQ
SRLDTEQDAI KRMETVLALV ERFPTEETAP GKGPTLQECA HMFETLQTDY YEEYKTMGLG
DLAVAVVHPL LKEKLSSWDP LKDSSYCLED IGQWRAILES QDMHSSGPHS NMDPYHRLLW
EVWIPVMRSC VSTWQPRLVG PMVDCLDLWA PLLPPWILDQ LLEQMILPRL QREVDNWNPL
TDTVPIHSWI HPWLPLLKAR LEPLYPPIRS KLSNALQRWH PSDASARLIL QPWKNVFTAG
AWEAFMVKNI IPKLALCLEE LVINPHQQQM EPFHWVMDWE GMLSPSSLVS LLDKNFFPKW
LQVLCSWLSN SPNYEEITKW YLGWKSMFSD VLLAQPLIKE KFNEALDIMN RAVSSGGYMQ
PGARENIAYL TQTERRKDFQ YEALQERRDA ESVAHRGIST GVPTNFKDLI QTKAEENNIV
FMPLVGKRHE GKQLYTFGRI VIYIDRGVVF VQGEKTWVPT SLQSLIDMAK
//
